Zhang, Y.; Gao, W.; Chen, Y.; Escajadillo, T.; Ungerleider, J.; Fang, R.; Christman, K.; Nizet, V.; Zhang, L.* "Self-assembled colloidal gel using cell membrane-coated nanosponges as building blocks", ACS Nano 2017, in press.
Esteban-Fernandez de Avila, B.; Angsantikul, P.; Li. J.; Gao, W.; Zhang, L.*, Wang, J. "Micromotors go in vivo: From petro dishes to live animals", Advanced Functional Materials 2017, in press.
LaGrow, A.; Coburn, P.; Miller, F.; Land, C.; Parkunan, S. M.; Luk, B.; Gao, W.; Zhang, L.; Callegan, M. "A novel biomimetic nanosponge protects the retina from the Enterococcus faecalis cytolysin", mSphere 2017, in press.
Uygun, M.; Jurado-Sanchez, B.; Uygun, D. A.; Singh, V. V.; Zhang, L.*, Wang, J. "Ultrasound-propelled nanowire motors enhance asparaginase enzymatic activity against cancer cells", Nanoscale 2017, in press.
Chen, C.; Chang, X.; Angsantikul, P.; Li, J.; Esteban-Fernandez de Avila, B.; Karshalev, E.; Liu, W.; Mou, F.; He, S.; Castillo, R.; Liang, Y.; Guan, J.; Zhang, L.*; Wang, J. "Chemotactic guidance of synthetic organic/inorganic payloads functionalized sperm micromotors", Advanced Biosystems 2017, in press.
Li, J.; Angsantikul, P.; Liu, W.; Esteban-Fernandez de Avila, B.; Chang, X.; Sandraz, E.; Liang, Y.; Zhu, S.; Zhang, Y.; Chen, C.; Gao, W.; Zhang, L.*, Wang, J. "Biomimetic platelet-camouflaged nanorobots for binding and isolation of biological threats", Advanced Materials 2017, in press.
Gao, W.; Chen, Y.; Zhang, Y.; Zhang, Q.; Zhang, L.* "Nanoparticle-based local antimicrobial drug delivery", Advanced Drug Delivery Reviews 2017, in press.
Kroll, A.; Fang, R.; Jiang, Y.; Zhou, J.; Wei, X.; Yu, C-L.; Gao, J.; Luk, B.; Dehaini, D.; Gao, W.; Zhang, L.* "Nanoparticulate delivery of cancer cell membrane elicits multi-antigenic antitumor immunity", Advanced Materials 2017, in press.
Lapek, J.; Fang, R.; Wei, X.; Li, P.; Wang, B.; Zhang, L.*; Gonzalez, D. "Biomimetic virulomics for capture and identification of cell-type specific effector proteins", ACS Nano 2017, in press.
Gao, W.; Esteban-Fernandez de Avila, B.; Zhang, L.*, Wang, J. "Targeting and isolation of cancer cells using micro/nanomotors", Advanced Drug Delivery Reviews 2017, in press.
Zhang, X.; Angsantikul, P.; Ying, M.; Zhuang, J.; Zhang, Q.; Wei, X.; Jiang, Y.; Zhang, Y.; Dehaini, D.; Chen, M.; Chen, Y.; Gao, W.; Fang, R.; Zhang, L.* "Remote loading of small molecule therapeutics into cholesterol-enriched cell membrane-derived vesicles", Angewandte Chemie International Edition 2017, 56, 14075-14079. [link]
Thamphiwatana, S.; Angsantikul, P.; Escajadillo, T.; Zhang, Q.; Olsan, J.; Luk, B.; Zhang, S.; Fang, R.; Gao, W.; Nizet, V.; Zhang, L.* "Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management", Proceedings of the National Academy of Sciences 2017,114, 11488-11493. [link]
Chai, Z.; Hu, X.; Wei, X.; Zhan, C.; Lu, L.; Jiang, K.; Su, B.; Ruan, H.; Ran, D.; Fang, R.; Zhang, L.*; Lu, W. "A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin- derived peptide for brain-targeted drug delivery", Journal of Controlled Release 2017, 264, 102-111. [link]
Chen, M.; Zhang, Y.; Zhang, L.* "Fabrication and characterization of a 3D bioprinted nanoparticle-hydrogel hybrid device for biomimetic detoxification", Nanoscale 2017, 9, 14506-14511. [link]
Zhang, Y.; Zhang, J.; Chen, W.; Angsantikul, P.; Spiekermann, K.; Fang, R.; Gao, W.; Zhang, L.* "Erythrocyte membrane-coated nanogel for combinatorial antivirulence and responsive antimicrobial delivery against Staphylococcus aureus infection", Journal of Controlled Release 2017, 263, 185-191. [link]
Zhuang, J.; Fang, R.; Zhang, L.* "Preparation of particulate polymeric therapeutics for medical applications",  Small Methods 2017, 1, 1700147. [link]
Wei, X.; Gao, J.; Wang, F.; Ying, M.; Angsantikul, P.; Kroll, A.; Zhou, J.; Gao, W.; Lu, W.; Fang, R.; Zhang, L.* "In situ capture of bacterial toxins for antivirulence vaccination", Advanced Materials 2017, 29, 1701644. [link]
Esteban-Fernandez de Avila, B.; Angsantikul, P.; Li, J.; Lopez-Ramirez, M.; Ramirez-Herrera, D.; Thamphiwatana, S.; Chen, C.; Delezuk, J.; Ramez, V.; Zhang, L.*; Wang, J. "Micromotor-enabled active drug delivery for in vivo treatment of stomach infection", Nature Communications 2017, 8, 272. [link]
Escajadillo, T.; Olson, J.; Luk, B.; Zhang, L.*; Nizet, V. "A red blood cell-camouflaged nanoparticle counteracts streptolysin O-mediated virulence phenotypes of invasive group A Streptococcus", Frontiers in Pharmacology 2017, 8, 477. [link]
Esteban-Fernandez de Avila, B.; Ramirez-Herrera, D. E.; Campuzano, S.; Angsantikul, P.; Zhang, L.*, Wang, J. "Nanomotor-enabled pH-responsive intracellular delivery of caspase-3: Towards rapid cell apoptosis", ACS Nano 2017, 11, 5367-5374. [link]
Huang, Q.; Lee, J.; Arce, F. T.; Yoon, I.; Angsantikul, P.; Liu, J.; Shi, Y.; Villanueva, J.; Thamphiwatana, S.; Ma, X.; Zhang, L.; Chen, S.; Lal, R.; Sirbuly, D. "Nanofiber optic force transducers with sub-piconewton resolution via near-field plasmon-dielectric interactions", Nature Photonics 2017, 11, 352-357. [link]
Dehaini, D.; Wei, X.; Fang, R.; Masson, S.; Angsantikul, P.; Luk, B.; Zhang, Y.; Ying, M.; Jiang, Y.; Kroll, A.; Gao, W.; Zhang, L.* "Erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization", Advanced Materials 2017, 29, 1606209. [link] [journal cover]
Hu, J.; Bernatchez, C.; Zhang, L.; Xia X.; Kleinerman, E.; Hung, M-C.; Hwu, P.; Li, S. "Induction of NKG2D ligands on solid tumors requires tumor-specific CD8+ T cell and histone acetyltranserases", Cancer Immunology Research 2017, 5, 300-311. [link]
Fang, R.; Jiang, Y.; Fang, J.; Zhang, L.* "Cell membrane-derived nanomaterials for biomedical applications", Biomaterials 2017, 128, 69-83. [link]
Li, J.; Esteban-Fernandez de Avila, B.; Gao, W.; Zhang, L.*; Wang, J. "Micro/nanorobots for biomedicine: delivery, surgery, sensing and detoxification", Science Robotics 2017, 2, eaam6431. [link]
Li, J.; Angsantikul, P.; Liu, W.; Esteban-Fernandez de Avila, B.; Thamphiwatana, S.; Xu, M.; Sandraz, E.; Wang, X.; Delezuk, J.; Gao, W.; Zhang, L.*; Wang, J. "Micromotors spontaneously neutralize gastric acid for pH-responsive payload release", Angewandte Chemie International Edition 2017, 56, 2165-2161. [link]
Kroll, A.; Fang, R.; Zhang, L.* "Biointerfacing and applications of cell membrane-coated nanoparticles", Bioconjugate Chemistry 2017, 28, 23-32. [link]
Hopper, M.; Yun, J.; Zhou, B.; Le, C; Kehoe, K.; Le, R.; Hill, R.; Jongeward, G.; Debnath, A.; Zhang, L.; Miyamoto, Y.; Eckmann, L.; Lan, K.; Wrischnik, L. "Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo", International Journal of Antimicrobial Agents 2016, 48, 690-694. [link]
Wei, X.; Gao, J.; Fang, R.; Luk, B.; Kroll, A.; Dehaini, D.; Zhou, J.; Kim, H. W.; Gao, W.; Lu, W.; Zhang, L.* "Nanoparticles camouflaged in platelet membrane coating as an antibody decoy for the treatment of immune thrombocytopenia", Biomaterials 2016, 111, 116-123. [link]
Li, J.; Thamphiwatana, S.; Liu, W.; Esteban-Fernandez de Avila, B.; Angsantikul, P.; Sandraz, E.; Wang, J.; Xu, T.; Soto, F.; Ramez, V.; Wang, X.; Gao, W.; Zhang, L.*, Wang, J. "Enteric micromotor can selectively position and spontaneously propel in the gastrointestinal tract", ACS Nano 2016, 10, 9536-9542. [link]
Highlighted: Chemical & Engineering News October 18, 2016. [link]
Zhang, Q.; Li, J.; Gao, W.; Zhang, L.* "Nanoparticles for ocular drug delivery" in Ophthalmic Disease Mechanisms and Drug Discovery (Zhang, K., Ed), World Scientific Press, 2016, 197-225.
Dehaini, D.; Fang, R.; Luk, B.; Pang, Z.; Hu, C-M.; Kroll, A.; Yu, C. L.; Gao, W.; Zhang, L.* "Ultra-small lipid-polymer hybrid nanoparticles for tumor-penetrating drug delivery", Nanoscale 2016, 8, 14411-14419. [link]
Zhang, Y.; Zhang, J.; Chen, M.; Gong, H.; Thamphiwatana, S.; Eckmann, L.; Gao, W.; Zhang, L.* "A bioadhesive nanoparticle-hydrogel hybrid system for localized antimicrobial drug delivery", ACS Applied Materials & Interfaces 2016, 8, 18367-18374. [link]
Dehaini, D.; Fang, R.; Zhang, L.* "Biomimetic strategies for targeted nanoparticle delivery", Bioengineering & Translational Medicine 2016, 1, 30-46. [link]
Fang, R.; Zhang, L.* "Nanoparticle-based modulation of the immune system", Annual Review of Chemical and Biomolecular Engineering 2016, 7, 305-326. [link]
Gao, W.; Zhang, Y.; Zhang, Q.; Zhang, L.* "Nanoparticle-hydrogel: A hybrid biomaterial system for localized drug delivery", Annals of Biomedical Engineering 2016, 44, 2049-2061. [link]
Chen, W.; Zhang, Q.; Luk, B.; Fang, R.; Liu, Y.; Gao, W.; Zhang, L.* "Coating nanofiber scaffolds with beta cell membrane to promote cell proliferation and function", Nanoscale 2016, 8, 10364-10370. [link]
Luk, B.; Fang, R.; Hu, C-M.; Copp, J.; Thamphiwatana, S.; Dehaini, D.; Gao, W.; Zhang, K.; Li, S.; Zhang, L.* "Safe and immunocompatible nanocarriers cloaked in RBC membranes for drug delivery to treat solid tumors", Theranostics 2016, 6, 1004-1011. [link]
Lin, H.; Ouyang, H.; Zhu, J.; Huang, S.; Liu, Z.; Chen, S.; Cao, G.; Li, G.; Signer, R.; Xu, Y.; Chung, C.; Zhang, Y.; Lin, D.; Patel, S.; Wu, F.; Cai, H.; Hou, J.; Wen, C.; Jafari, M.; Liu, X.; Luo, L.; Zhu, J.; Qiu, A.; Hou, R.; Chen, B.; Chen, J.; Granet, D.; Heichel, C.; Shang, F.; Li, X.; Krawczyk, M.; Skowronska-Krawczyk, D.; Wang, Y.; Shi, W.; Chen, D.; Zhong, Z.; Zhong, S.; Zhang, L.; Chen, S.; Morrison, S.; Maas, R.; Zhang, K.; Liu. Y. "Lens regeneration using endogenous stem cells with gain of visual function", Nature 2016, 531, 323-328. [link]
Highlighted: Nature 2016, 531, 309-310 (News & Views). [link]
Wang, F.; Fang, R.; Luk, B.; Hu, C-M.; Thamphiwatana, S.; Dehaini, D.; Angsantikul, P.; Kroll, A.; Pang, Z.; Gao, W.; Lu, W.; Zhang, L.* "Nanoparticle-based anti-virulence vaccine for the management of methicillin-resistant Staphylococcus aureus skin infection", Advanced Functional Materials 2016, 26, 1628-1635. [link]
Angell, C.; Xie, S.; Zhang, L.; Chen, Y. "DNA nanotechnology for precise control over drug delivery and gene therapy", Small 2016, 12, 1117-1132. [link]
Luk, B.; Zhang, L.* "Cell membrane-camouflaged nanoparticles for drug delivery", Journal of Controlled Release 2015, 220, 600-607. [link]
Wu, Z.; Li, J.; Esteban-Fernandez de Avila, B.; Li, T.; Gao, W.; He, Q.; Zhang, L.*; Wang, J. "Water-powered cell-mimicking Janus micromotor", Advanced Functional Materials 2015, 25, 7497-7501. [link]
Fang, R.; Kroll, A.; Zhang, L.* "Nanoparticle-based manipulation of antigen presenting cells for cancer immunotherapy", Small 2015, 11, 5483-5496. [link] [journal cover]
Gao, W.; Zhang, L.* "Coating nanoparticles with cell membranes for targeted drug delivery", Journal of Drug Targeting 2015, 23, 619-626. (Special Issue Honoring Dr. Robert Langer) [link]
Angsantikul, P.; Thamphiwatana, S.; Gao, W.; Zhang, L.* "Cell membrane-coated nanoparticles as an emerging antibacterial vaccine platform", Vaccines 2015, 3, 814-828. [link]
Hu, C-M.; Fang, R.; Wang, K-C.; Luk, B.; Thamphiwatana, S.; Dehaini, D.; Nguyen, P.; Angsantikul, P.; Wen, C.; Kroll, A.; Carpenter, C.; Ramesh, M.; Qu, V.; Patel, S.; Zhu, J.; Shi, W.; Hofman, F.; Chen, T.; Gao, W; Zhang, K.; Chien, S.; Zhang, L.* "Nanoparticle biointerfacing by platelet membrane cloaking", Nature 2015, 526, 118-121. [link]
Highlighted: Nature 2015, 526, 47-48 (News & Views). [link]
                    Nature News September 16, 2015. [link]
                    Nature Podcast September 16, 2015. [link]
                    Science Translational Medicine 2015, 7 (307), 307ec169. [link]
Zhang, J., Gao, W.; Fang, R.; Dong, A.; Zhang, L.* "Synthesis of nanogels via cell membrane-templated polymerization", Small 2015, 11, 4309-4313. [link]
Skowronska-Krawczyk, D.; Zhao, L.; Zhu, J.; Weinreb, R.N.; Cao, G.; Luo, J.; Flagg, K.; Patel, S.; Wen C.; Krupa, M.; Luo, H.; Ouyang, H.; Lin, D.; Wang, W.; Li, G.; Xu, Y.; Li, O.; Chung, C.; Yeh, E.; Jafari, M.; Ai, M.; Zhong, Z.; Shi, W.; Zheng, L.; Krawczyk, M.; Chen, D.; Shi, C.; Zin, C.; Zhu, J.; Mellon, P.L.; Gao, W.; Abagyan, R.; Zhang, L.; Sun, X.; Zhong, S.; Zhuo, Y,; Rosenfeld, M.G.; Liu, Y.; Zhang, K. "P16INK4a upregulation mediated by SIX6 defines retinal ganglion cell pathogenesis in glaucoma", Molecular Cell 2015, 59, 931-940. [link]
Wu, Z.; Esteban-Fernandez de Avila, B.; Martin, A.; Christianson, C.; Gao, W.; Thamphiwatana, S.; Escarpa, A.; He, Q.; Zhang, L.*; Wang, J. "RBC micromotors carrying multiple cargos towards potential theranostic applications", Nanoscale 2015, 7, 13680-13686. [link]
Fang, R.; Luk, B.; Hu, C-M.; Zhang, L.* "Engineered nanoparticles mimicking cell membranes for toxin neutralization", Advanced Drug Delivery Reviews 2015, 90, 69-80. [link] [journal cover]
Zhang, L.*; Leroux, J-C. "Current and forthcoming approaches for systemic detoxification", Advanced Drug Delivery Reviews 2015, 90, 1-2. (Editorial) [link]
Zhao, L.; Chen, X.; Zhu, J.; Xi, Y.; Yang, X.; Hu, L.; Patel, S.; Jin, X.; Lin, D.; Wu, F.; Flagg, K.; Cai, H.; Li, G.; Cao, G.; Ouyang, H.; Chen, D.; Wen, C.; Qiu, A.; Yeh, E.; Wang, W.; Hu, X.; Grob, S.; Abagyan, R.; Lin, Y.; Su, Z.; Tjondro, H.; Zhao, X.; Luo, H.; Hou, R.; Chung, C.; Perry, J.; Gao, W.; Kozak, I.; Granet, D.; Li, Y.; Sun, X.; Wang, J.; Zhang, L.*; Liu, Y.; Yan, Y.; Zhang, K. "Lanosterol reverses protein aggregation in cataract", Nature 2015, 523, 607-611. [link]
Highlighted: Nature 2015, 523, 540-541 (News & Views). [link]
                    Science July 22, 2015. [link]
Esteban-Fernandez de Avila, B.; Martin, A.; Soto, F.; Ramirez, M.; Campuzano, S.; Vasquez-Machado, G. M.; Gao, W.; Zhang, L.*; Wang, J. "Single cell real time miRNA sensing based on nanomotors", ACS Nano 2015, 9, 6756-6764. [link]
Pang, Z.; Hu, C-M. J.; Fang, R. H.; Luk, B. T.; Gao, W.; Wang, F.; Chuluun, E.; Angsantikul, P.; Thamphiwatana, S.; Lu, W.; Jiang, X.; Zhang, L.* "Detoxification of organophosphate poisoning using nanoparticle bioscavengers", ACS Nano 2015, 9, 6450-6458. [link]
Wu, Z.; Li, T.; Gao, W.; Xu, T.; Jurado-Sanchez, B.; Li, J.; Gao, W.; He, Q.; Zhang, L.*; Wang, J. "Cell membrane-coated synthetic nanomotors for effective biodetoxification", Advanced Functional Materials 2015, 25, 3881-3887. [link]
Wang, F.; Gao, W.; Thamphiwatana, S.; Luk, B.; Angsantikul, P.; Zhang, Q.; Hu, C-M.; Fang, R.; Copp, J.; Pornpattananangkul, D.; Lu, W.; Zhang, L.* "Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection", Advanced Materials 2015, 27, 3437-3443. [link] [journal cover]
Krishnamurthy, S.; Vaiyapuri, R.; Zhang, L.; Chan, J. "Lipid-coated polymeric nanoparticles for cancer drug delivery", Biomaterials Science, 2015, 3, 923-936. [link]
Futalan, D.; Saenz, R.; Bharati, I.; Seible, D.; Zhang, L.; Esener, S.; Messmer, B.; Larsson, M.; Messmer, D. "Enhanced anti-tumor immune response and delay of tumor development in HER2 mice immunized with immunostimulatory peptides in PLGA nanoparticles", Breast Cancer Research 2015, 17, 48. [link]
Jung, S. W.; Thamphiwatana, S.; Zhang, L.*; Obonyo, M. "Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori", PLOS ONE 2015, 10(3), e0116519. [link]
Sanchez-Gaytan, B. L.; Fay, F.; Lobatto, M. E.; Tang, J.; Ouimet, M.; Kim, Y. T.; van der Staay, S.; van Rijs, S.; Priem, Z.; Zhang, L.; Fisher, E. A.; Moore, K.; Langer, R.; Fayad, Z. A.; Mulder, W. J. "HDL-mimetic PLGA nanoparticle for the targeting of atherosclerosis plaque macrophages", Bioconjugate Chemistry, 2015, 26, 443-451. [link]
Gao, W.; Zhang, L.* "Engineering red blood cell membrane-coated nanoparticles for broad biomedical applications", AIChE Journal 2015, 61, 738-746. (Perspective: 2014 AIChE Allan P. Colburn Award) [link] [journal cover]
Highlighted: CEP Magazine March, 2015. [link]
Gao, W.; Fang, R.; Thamphiwatana, S.; Luk, B.; Li, J.; Angsantikul, P.; Zhang, Q.; Hu, C-M.; Zhang, L.* "Modulating antibacterial immunity via bacterial membrane-coated nanoparticles", Nano Letters 2015, 15, 1403-1409. [link]
Gao, W.; Dong, D.; Thamphiwatana, S.; Li, J.; Gao, W.; Zhang, L.*; Wang, J. "Artificial micromotors in the mouse’s stomach: A step towards in vivo use of synthetic motors", ACS Nano 2015, 9, 117-123. [link]
Highlighted: Chemical & Engineering News January 21, 2015. [link]
Wu, Z.; Li, T.; Li, J.; Gao, W.; Xu, T.; Christianson, C.; Gao, W.; Galarnyk, M.; He, Q.; Zhang, L.*; Wang, J. "Turning erythrocytes to functional micromotors", ACS Nano 2014, 8, 12041-12048. [link]
Luk, B.; Zhang, L.* "Current advances in polymer-based nanotheranostics for cancer treatment and diagnosis", ACS Applied Materials & Interfaces 2014, 6, 21859-21873. [link]
Thamphiwatana, S.; Gao, W.; Obonyo, M.; Zhang, L.* "In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation", Proceedings of the National Academy of Sciences 2014, 111, 17600-17605. [link]
Highlighted: Nature Reviews Gastroenterology & Hepatology 2015, 12, 5. [link]
Thamphiwatana, S.; Gao, W.; Pornpattananangkul, D.; Zhang, Q.; Fu, V.; Li, J.; Li, J.; Obonyo, M.; Zhang, L.* "Phospholipase A2-responsive antibiotic delivery via nanoparticle-stabilized liposomes for the treatment of bacterial infection", Journal of Materials Chemistry B 2014, 2, 8201-8207. [link]
Gao, W.; Thamphiwatana, S.; Angsantikul, P.; Zhang, L.* "Nanoparticle approaches against bacterial infections", WIREs Nanomedicine & Nanobiotechnology 2014, 6, 532-547. [link]
Copp, J.; Fang, R. Luk, B.; Hu, C-M.; Gao, W.; Zhang, K.; Zhang, L.* "Clearance of pathological antibodies using biomimetic nanoparticles", Proceedings of the National Academy of Sciences 2014, 111, 13481-13486. [link]
Highlighted: Proceedings of the National Academy of Sciences 2014, 111, 13243-13244. [link]
Hu, C-M.; Zhang, L.* "Nanotoxoid vaccines", Nano Today 2014, 9, 401-404. [link]
Sattayasamitsathit, S.; Kou, H.; Gao, W.; Thavarajah, W.; Kaufmann, K.; Zhang, L.*; Wang, J. "Fully-loaded micromotors for combinatorial delivery and autonomous release of cargoes", Small 2014, 10, 2830-2833. [link]
Ouyang, H.; Xue, Y.; Lin, Y.; Zhang, X.; Xi, L.; Patel, S.; Cai, H.; Luo, J.; Zhang, M.; Zhang, M.; Yang, Y.; Li, G.; Li, H.; Jiang, W.; Yeh, E.; Lin, J.; Pei, M.; Zhu, J.; Cao, G.; Zhang, L.; Yu, B.; Chen, S.; Fu, X-D.; Liu, Y.; Zhang, K. "WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis", Nature 2014, 511, 358-361. [link]
Yu, F-X.; Luo, J.; Mo, J-S.; Liu, G.; Kim, Y. C. ; Meng, Z.; Zhao, L.; Peyman, G.; Ouyang, H.; Jiang, W.; Chen, X.; Zhang, L.; Wang, C-Y.; Bastian, B. C.; Zhang, K.; Guan, K-L. "Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP", Cancer Cell 2014, 25, 822-830. [link]
Fang, R.; Zhang, L.* "Combinatorial nanotherapeutics: Rewiring, then killing, cancer cells", Science Signaling 2014, 7, pe13. [link]
Fang, R.; Hu, C-M.; Luk, B.; Gao, W.; Copp, J.; Tai, Y.; O'Connor, D.; Zhang, L.* "Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery", Nano Letters 2014, 14, 2181-2188. [link]
Gao, W.; Vecchio, D.; Li, J.; Zhu, J.; Zhang, Q.; Fu, V.; Li, J.; Thamphiwatana, S.; Lu, D.; Zhang, L.* "Hydrogel containing nanoparticle-stabilized liposomes for topical antimicrobial delivery", ACS Nano 2014, 8, 2900-2907. [link]
Highlighted: Nature Nanotechnology 2014, 9, 161. [link]
Luk, B.; Hu, C-M.; Fang, R.; Dehaini, D.; Carpenter, C.; Gao, W.; Zhang, L.* "Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles", Nanoscale 2014, 6, 2730-2737. [link]
Hu, J.; Zhu, S.; Xia, X.; Zhang, L.; Kleinerman, E. S.; Li, S. "CD8+T cell-specific induction of NKG2D receptor by doxorubicin plus interleukin-12 and its contribution on CD8+T cell accumulation in tumors", Molecular Cancer 2014, 13, 34. [link]
Sukumar, R.; Sethi, M.; Karve, S.; Werner, M.; Moore, D.; Zhang, L.; Wang, A. Z. "Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicity", Nanoscale 2014, 6, 2321-2327. [link]
Hu, C-M.; Fang, R.; Luk, B.; Zhang, L.* "Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies", Nanoscale 2014, 6, 65-75. [link]
Hu, C-M.; Fang, R.; Luk, B.; Zhang, L.* "Nanoparticle-detained toxins for safe and effective vaccination",       Nature Nanotechnology 2013, 8, 933-938. [link]
Highlighted: Science 2013, 342, 1418. [link]
                    NIH Director's Blog, December 12, 2013. [link]
                    MIT Technology Review, January 3, 2014. [link]
Gao, W.; Hu, C-M.; Fang, R.; Zhang, L.* "Liposome-like nanostructures for drug delivery", Journal of Materials Chemistry B, 2013, 1, 6569-6585. [link]
Fang, R.; Hu, C-M.; Chen, K.; Luk, B.; Carpenter, C.; Gao, W.; Li, S.; Zhang, D-E.; Lu, W.; Zhang, L.* "Lipid-insertion enables targeting functionalization of erythocyte membrane-cloaked nanoparticles", Nanoscale 2013, 5, 8884-8888. [link]
Pornpattananangkul, D.; Fu, V.; Thamphiwatana, S.; Zhang, L.; Chen, M.; Vecchio, J.; Gao, W.; Huang, C-M.; Zhang, L.* "In vivo treatment of Propionibacterium acnes infection with liposomal lauric acids", Advanced Healthcare Materials 2013, 2, 1322-1328. [link]
Thamphiwatana, S.; Fu, V.; Zhu, J.; Lu, D.; Gao, W.; Zhang, L.* "Nanoparticle-stabilized liposomes for pH-responsive gastric drug delivery", Langmuir 2013, 29, 12228-12233. [link]
Aryal, S.; Hu, C-M.; Fang, R.; Dehaini, D.; Carpenter, C.; Zhang, D-E.; Zhang, L.* "Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release", Nanomedicine 2013, 8, 1271-1280. [link]
Gao, W.; Hu, C-M.; Fang, R.; Luk, B.; Su, J.; Zhang, L.* "Surface functionalization of gold nanoparticles with red blood cell membranes", Advanced Materials 2013, 25, 3549-3553. [link] [journal cover]
Hu, C-M.; Fang, R.; Copp, J.; Luk, B.; Zhang, L.* "A biomimetic nanosponge that absorbs pore-forming toxins", Nature Nanotechnology 2013, 8, 336-340. [link] [animation]
Highlighted: Science Translational Medicine 2013, 5 (184), 184ec78. [link]
                    Nano Today, 2013, 8, 217-218. (News and Opinions) [link]
                    MIT Technology Review, April 14, 2013. [link]
Hu, C-M.; Fang, R.; Luk, B.; Chen, K.; Carpenter, C.; Gao, W.; Zhang, K.; Zhang, L.* "'Marker-of-self' functionalizaton of nanoscale particles through a top-down cellular membrane coating approach", Nanoscale 2013, 5, 2664-2668. [link]
Kong, S.; Sartor, M.; Hu, C-M.; Zhang, W.; Zhang, L.*; Jin, S. "Magnetic field activated lipid-polymer hybrid nanoparticles for stimuli-responsive drug release", Acta Biomaterialia 2013, 9, 5447-5452. [link]
Zhao, J.; Sun, W.; Cho, H. M.; Ouyang, H.; Li, W.; Lin, Y.; Do, J.; Zhang, L.; Ding, S.; Liu, Y.; Lu, P.; Zhang, K. "Integration and long distance axonal regeneration in the central nervous system from transplanted primitive neural stem cells", Journal of Biological Chemistry 2013, 288, 164-168. [link]
Gao, W.; Zhang, L.* "Unleash the forces within", Nature Chemistry 2012, 4, 971-972. [link]
Luk, B. T.; Fang, R. H.; Zhang, L.* "Lipid- and polymer-based nanostructures for cancer theranostics", Theranostics 2012, 2, 1117-1126. [link]
Fang, R.; Chen, K.; Aryal, S.; Hu, C-M.; Zhang, K.; Zhang, L.* "Large-scale synthesis of lipid-polymer hybrid nanoparticles using a multi-inlet vortex reactor", Langmuir 2012, 28, 13824-13829. [link]
Hu, C-M.; Fang, R. H.; Zhang, L.* "Erythrocyte-inspired delivery systems", Advanced Healthcare Materials      2012, 1, 537-547. [link]
Obonyo, M.; Zhang, L.; Thamphiwatana, S.; Pornpattananangkul, D.; Fu, V.; Zhang, L.* "Antibacterial activities of liposomal linolenic acids against antibiotic-resistant Helicobacter pylori", Molecular Pharmaceutics 2012, 9, 2677-2685. [link]
Shaw, P. X.; Zhang, L.; Zhang, M.; Du, H.; Zhao, L.; Lee, C.; Crob, S.; Lim, S. L.; Hughes, G.; Lee, J.; Bedell, M.; Nelson, M. H.; Lu, F.; Luo, J.; Ouyang, H.; Tu, Z.; Su, Z.; Zhu, J.; Wei, X.; Feng, Z.; Duan, Y.; Yang, Z.; Ferreyra, F.; Bartsch, D-U.; Kozak, I.; Zhang, L.; Lin, F.; Sun, H.; Feng, H.; Zhang, K. "Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids", Proceedings of the National Academy of Sciences 2012, 109, 13757-13762. [link]
Zhang, K.; Zhang, L.; Weinreb, R. N. "Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma", Nature Reviews Drug Discovery 2012, 11, 541-559. [link]
Fang, R. H.; Hu, C-M.; Zhang, L.* "Nanoparticles disguised as red blood cells to evade the immune system", Expert Opinion on Biological Therapy 2012, 12, 385-389. [link]
Aryal, S.; Hu, C-M.; Zhang, L.* "Synthesis of Ptsome: A platinum-based liposome-like nanostructure", Chemical Communications 2012, 48, 2630-2632. [link]
Hu, C-M.; Zhang, L.* "Nanoparticle-based combination therapy toward overcoming drug resistance in cancer", Biochemical Pharmacology 2012, 83, 1104-1111. [link]
Gao, W.; Kagan, D.; Pak, O. ; Clawson, C.; Campuzano, S.; Erdene, E. C.; Fullerton, E.; Zhang, L.*; Lauga, E.; Wang, J. "Cargo-towing fuel-free magnetic nanomotors for targeted drug delivery", Small 2012, 8, 460-467. [link]
Aryal, S.; Hu, C-M.; Fu, V.; Zhang, L.* "Nanoparticle drug delivery enhances the cytotoxicity of hydrophobic- hydrophilic drug conjugates", Journal of Materials Chemistry 2012, 22, 994-999. [link]
Clawson, C.; Ton, L.; Aryal, S.; Fu, V.; Esener, S.; Zhang, L.* "Synthesis and characterization of lipid-polymer hybrid nanoparticles with pH-triggered PEG shedding", Langmuir 2011, 27, 10556-10561. [link]
Fang, R. H.; Zhang, L.* "Dispersion-based methods for the engineering and manufacture of polymeric nanoparticles for drug delivery applications", Journal of Nanoengineering and Nanomanufacturing 2011, 1, 106-112. [link]
Aryal, S.; Hu, C-M.; Zhang, L.* "Polymeric nanoparticles with precise ratiometric control over drug loading for combination therapy", Molecular Pharmaceutics 2011, 8, 1401-1407. [link]
Hu, C-M.; Zhang, L.; Aryal, S.; Cheung, C.; Fang, R. H.; Zhang, L.* "Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform", Proceedings of the National Academy of Sciences 2011, 108, 10980-10985. [link]
Highlighted: Nano Today 2011, 6, 327. (News and Opinions) [link]
                    National Academy of Engineering, "Engineering Innovation" Radio News [link]
Balasubramanian, S.; Kagan, D.; Hu, C-M.; Campuzano, S.; Lobo-Castañon, M. J.; Lim, N.; Kang, D.; Zhang, L.*; Wang, J. "Nanomachine enabled selection and isolation of cancer cells in complex media", Angewandte Chemie International Edition 2011, 50, 4161-4164. [link] [journal cover]
Highlighted: Angewandte Chemie International Edition 2011, 50, 7220-7221. [link]
                    Chemical & Engineering News 2011, 89 (18), 6. [link]
Chen, C-H.; Wang, Y.; Liu, Y-T.; Zouboulis, C.; Gallo, R. L.; Zhang, L.*; Hsieh, M-F.; Huang, C-M. "An innate bactericidal oleic acid effective against skin infection of methicillin-resistant Staphylococcus aureus: a therapy concordant with evolutionary medicine", Journal of Microbiology and Biotechnology 2011, 21, 391-399. [link]
Nakatsuji, T.; Tang, D-C.; Zhang, L.; Gallo, R. L.; Huang, C-M. "Propionibacterium acnes CAMP factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment",
PLOS ONE 2011, 6(4), e14797. [link]
Pornpattananangkul, D.; Zhang, L.; Olson, S.; Aryal, S.; Obonyo, M.; Vecchio, K.; Huang, C-M.; Zhang, L.* "Bacterial toxin-triggered drug release from gold nanoparticle-stabilized liposomes for the treatment of bacterial infection", Journal of the American Chemical Society 2011, 133, 4132-4139. [link]
Highlighted: Chemical & Engineering News 2011, 89 (10), 42. [link]
Clawson, C.; Esener, S.; Zhang, L.* "Lipid-Polymer Nanomaterials" in Polymeric Nanomaterials (Kumar, C., Ed), Wiley-VCH Press, 2011, 259-284.
Huang, C-M.; Chen, C-H.; Pornpattananangkul, D.; Zhang, L.; Chan, M.; Hsieh, M-F.; Zhang, L.* "Eradication of drug resistant Staphylococcus aureus by liposomal oleic acids", Biomaterials 2011, 32, 214-221. [link]
Kagan, D.; Laocharoensuk, R.; Zimmerman, M.; Clawson, C.; Balasubramanian, S.; Kang, D.; Bishop, D.; Sattayasamitsathit, S.; Zhang, L.*; Wang, J. "Rapid delivery of drug carriers propelled and navigated by catalytic nanoshuttles", Small 2010, 6, 2741-2747. [link]
Highlighted: Nature Materials 2010, 9, 958. [link]
Fang, R. H.; Aryal, S.; Hu, C-M.; Zhang, L.* "Quick synthesis of lipid-polymer hybrid nanoparticles with low polydispersity using a single-step sonication method", Langmuir 2010, 26, 16958-16962. [link]
Zhang, L.; Zhang, L*"Lipid-polymer hybrid nanoparticles: synthesis, characterization and applications",
Nano LIFE 2010, 1, 163-173. [link]
Hu, C-M.; Aryal, S.; Zhang, L.* "Nanoparticles assisted combination therapies for effective cancer treatment", Therapeutic Delivery 2010, 1, 323-334. [link]
Aryal, S.; Hu, C-M.; Zhang, L.* "Combinatorial drug conjugation enabled nanoparticle dual drug delivery",
Small 2010, 6, 1442-1448. [link]
Chumbimuni-Torres, K. Y.; Wu, J.; Clawson, C.; Galik, M.; Walter, A.; Flechsig, G-U.; Bakker, E.; Zhang, L.*; Wang, J. "Amplified potentiometric transduction of DNA hybridization using ion-loaded liposomes", Analyst 2010, 135, 1618-1623. [link]
Hu, C-M,; Kaushal, S.; Tran Cao, H. S.; Aryal, S.; Sartor, M.; Esener, S.; Bouvet, M.; Zhang, L.* "Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cells", Molecular Pharmaceutics 2010, 7, 914-920. [link]
Pornpattananangkul, D.; Olson, S.; Aryal, S.; Sartor, M.; Huang, C-M.; Vecchio, K. S.; Zhang, L.* "Stimuli-responsive liposome fusion mediated by gold nanoparticles", ACS Nano 2010, 4, 1935-1942. [link]
Highlighted: Nanomedicine 2010, 5, 530. [link]
Wang, A.; Yuet, K.; Zhang, L.; Gu, F.; Huynh-Le, M.; Radovic-Moreno, A.; Langer, R.; Farokhzad, O. C. "ChemoRad nanoparticles: A novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation", Nanomedicine 2010, 5, 361-368. [link]
Valencia, P.; Basto, P., Zhang, L.; Rhee, M.; Langer, R.; Farokhzad, O. C.; Karnik, R. "Single-step assembly of homogeneous lipid-polymeric and lipid-quantum dots nanoparticles enabled by microfluidic rapid mixing",
ACS Nano 2010, 4, 1671-1679. [link]
Nakatsuji, T.; Kao, M. C.; Zhang, L.; Zouboulis, C. C.; Gallo, R. L.; Huang, C-M. "Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating ß-defensin-2 expression", Journal of Investigative Dermatology 2010, 130, 985-994. [link]
Chan, J.; Zhang, L.; Tong, R.; Ghosh, D.; Gao, W.; Liao, G.; Yuet, K.; Gray, D.; Rhee, J-W.; Cheng, J.; Golomb, G.; Libby, P.; Langer, R.; Farokhzad, O. C. "Spatiotemporal controlled delivery of nanoparticles to injured vasculature", Proceedings of the National Academy of Sciences 2010, 107, 2213-2218. [link]
Chan, J.; Valencia, M. P.; Zhang, L.; Langer, R.; Farokhzad, O. C. "Polymer nanoparticles for drug delivery" in Cancer Nanotechnology: Methods and Protocols (Grobmyer, S. and Moudgil, B., Eds.), Springer Press, USA, 2010, 163-175. [link]
Aryal, S.; Hu, C-M.; Zhang, L.* "Polymer-cisplatin conjugate nanoparticles for acid-responsive drug delivery",
ACS Nano 2010, 4, 251-258. [link]
Zhang, L.*; Pornpattananangkul, D.; Hu, C-M.; Huang, C-M. "Development of nanoparticles for antimicrobial drug delivery", Current Medicinal Chemistry 2010, 17, 585-594. [link]
Hu, C-M.; Zhang, L.* "Therapeutic nanoparticles to combat cancer drug resistance", Current Drug Metabolism 2009, 10, 836-841. [link]
Mora, L.; Chumbimuni-Torres, K. Y.; Clawson, C.; Hernandez, L.; Zhang, L.*; Wang, J. "Real-time electrochemical monitoring of drug release from therapeutic nanoparticles", Journal of Controlled Release 2009, 140, 69-73. [link]
Yang, D.; Pornpattananangkul, D.; Nakatsuji, T.; Chan, M.; Carson, D.; Huang, C-M.; Zhang, L.* "The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes", Biomaterials 2009, 30, 6035-6040. [link]
Nakatsuji, T.; Kao, M. C.; Fang, J-Y.; Zouboulis, C. C.; Zhang, L.; Gallo, R. L.; Huang, C-M. "Antimicrobial property of lauric acid against propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris",
Journal of Investigative Dermatology 2009, 129, 2480-2488. [link]
Salvador-Morales, C.; Zhang, L.; Langer, R.; Farokhzad, O. C. "Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups", Biomaterials 2009, 30, 2231-2240. [link]
Chan, J.; Zhang, L.; Yuet, K.; Liao, G.; Rhee, J-W.; Langer, R.; Farokhzad, O. C. "PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery", Biomaterials 2009, 30, 1627-1634. [link]
Alexis, F.; Basto, P.; Levy-Nissenbaum, E.; Radovic-Moreno, A.; Zhang, L.; Pridgen, E.; Wang, A.; Molnar, S.; Westerhof K.; Farokhzad, O. C. "HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy", ChemMedChem 2008, 3, 1839-1843. [link]
Wang, B.; Zhang, L.; Bae, S. C.; Granick, S. "Nanoparticle-induced surface reconstruction of phospholipid membranes", Proceedings of the National Academy of Sciences 2008, 105, 18171-18175. [link]
Highlighted: Nature Nanotechnology 2008, doi:10.1038/nnano.2008.371. [link]
Wang, A.; Bagalkot, V.; Vasilliou, C.; Gu. F.; Alexis, F.; Zhang, L.; Shaikh, M. R.; Yuet, K.; Cima, M.; Langer, R.; Kantoff, P. W.; Bander, N. H.; Jon, S.; Farokhzad, O. C. "Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy", ChemMedChem 2008, 3, 1311-1315. [link]
Zhang, L. ; Chan, J.; Gu, F.; Rhee, J-W.; Wang, A.; Radovic-Moreno, A.; Alexis, F.; Langer, R.; Farokhzad, O. C. "Self-assembled lipid-polymer hybrid nanoparticles: A robust drug delivery platform", ACS Nano 2008, 2, 1696-1702. [link]
Wang, A.; Gu, F.; Zhang, L.; Chan, J.; Radovic-Modovic, A.; Shaikh, M. R.; Farokhzad, O. C. "Biofunctionalized targeted nanoparticles for therapeutic applications", Expert Opinion on Biological Therapy 2008, 8, 1063-1070. [link]
Zhang, L.; Gu, F.; Chan, J.; Wang, A.; Langer, R.; Farokhzad, O. C. "Nanoparticles in medicine: Therapeutic applications and developments", Clinical Pharmacology & Therapeutics 2008, 83, 761-769. [link]
Gu, F.; Zhang, L.; Teply, B.; Mann, N.; Wang, A.; Radovic-Moreno, A.; Langer, R.; Farokhzad, O. C. "Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers",
Proceedings of the National Academy of Sciences 2008, 105, 2586-2591. [link]
Bagalkot, V.; Zhang, L.; Levy-Nissenbaum, E.; Jon, S.; Kantoff, P. W.; Langer, R.; Farokhzad, O. C. "Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy and sensing of drug delivery based on bi-fluorescence resonance energy transfer", Nano Letters 2007, 7, 3065-3070. [link]
Zhang, L.; Radovic-Moreno, A.; Alexis, F.; Gu, F.; Basto, P. A.; Bagalkot, V.; Jon, S.; Langer, R.; Farokhzad, O. C. "Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates", ChemMedChem 2007, 2, 1268-1271. [link]
Yu, Y.; Anthony, S.; Zhang, L.; Bae, S. C.; Granick, S. "Cationic nanoparticles stabilize zwitterionic liposomes better than anionic ones", Journal of Physical Chemistry C 2007, 111, 8233-8236. [link]
Zhang, L.; Dammann, K.; Bae, S. C. Granick, S. "Ligand-receptor binding on nanoparticle-stabilized liposome surfaces", Soft Matter 2007, 3, 551-553. [link]
Zhang, L.; Granick, S. "Inter-leaflet diffusion coupling when polymer adsorbs onto one sole leaflet of a supported phospholipid bilayer", Macromolecules 2007, 40, 1366-1368. [link]
Zhang, L.; Hong, L.; Yu, Y.; Bae, S. C.; Granick, S. "Nanoparticle-assisted surface immobilization of phospholipid liposomes", Journal of the American Chemical Society 2006, 128, 9026-9027. [link]
Zhang, L.; Granick, S. "Dynamical heterogeneity in supported lipid bilayers", MRS Bulletin 2006, 31, 527-531. [link]
Anthony, S.; Zhang, L.; Granick, S. "Methods to track single-molecule trajectories", Langmuir 2006, 22, 5266-5272. [link]
Zhang, L.; Granick, S. "How to stabilize phospholipid liposomes (using nanoparticles)", Nano Letters 2006, 6, 694-698. [link]
Highlighted: Science 2006, 311, 1347. [link]; Nature Materials 2006, 5, 249. [link]
Zhang, L.; Spurlin, T. A.; Gewirth, A. A.; Granick, S. "Electrostatic stitching in gel-phase supported phospholipid bilayers", Journal of Physical Chemistry B 2006, 110, 33-35. [link]
Highlighted: Science 2005, 310, 1871. [link]
Zhang, L.; Granick, S. "Lipid diffusion compared in outer and inner leaflets of planar supported bilayers",
Journal of Chemical Physics 2005, 123, 211104/1-4. [link]
Zhang, L.; Granick, S. "Slaved diffusion in phospholipid bilayers", Proceedings of the National Academy of Sciences 2005, 102, 9118-9121. [link]