Papers

Nandhakumar, P.; Sun, L.; Li, Z.; Cheung, C.; Nguyen, L.; Ding, S.; Gao, W.; Zhang, L.*, Wang, J. "Biomimetic cell membrane layers for the detection of insulin and glucagon", Analytical Chemistry, 2024, in press.

Yu, Y.; Silva-Ayala, D.; Zhou, Z.; Peng, Y.; Fang, R.; Gao, W.; Griffiths, A.; Zhang, L.* "Cellular nanoparticles treat coronavirus infection in vivo", Nano Letters 2024, in press.

Kai, M.; Shen, W.; Wang, D.; Yu, Y.; Zhang, J.; Sun, L.; Fang, R.; Gao, W.; Zhang, L.* "Aptamer-encapsulated cellular nanoparticles for neurotoxin neutralization", Advanced Healthcare Materials 2024, in press.

Mundaca-Uribe, R.; Askarinam, N.; Fang, R.; Zhang, L.*; Wang, J. "Towards multifunctional robotic pills", Nature Biomedical Engineering 2024, 8, 1334-1346. [link]

Zhang, J.; Feng, K.; Shen, W.; Gao, W.; Zhang, L.* "Research advances of cellular nanoparticles as multiplex countermeasures", ACS Nano 2024, 18, 30211-30223. [link]

Guo, Z.; Zhu, A.; Fang, R.; Zhang, L.* "Viral and nonviral nanocarriers for in vivo CRISPR-based gene editing", Nano Research 2024, 17, 8904-8925. [link]

Wang, D.; Sun, L.; Shen, W.; Haggard, A.; Yu, Y.; Zhang, J.; Fang, R.; Gao, W.; Zhang, L.* "Neuronal membrane-derived nanodiscs for broad-spectrum neurotoxin detoxification", ACS Nano 2024, 18, 25069-25080. [link]

Zhou, Z.; Mukundan, N.; Zhang, J.; Wu, M.; Zhang, Q.; Wang, D.; Fang, R.; Gao, W.; Zhang, L.* "Macrophage-mimicking cellular nanoparticles scavenge proinflammatory cytokines in specimens of patients with inflammatory disorders", Advanced Science 2024, 11, 2401423. [link]

Guo, Z.; Zhu, A.; Wei, X.; Jiang, Y.; Yu, Y.; Noh, I.; Gao, W.; Fang, R.; Zhang, L.* "A genetically engineered neuronal membrane-based nanotoxoid elicits protective immunity against neurotoxins", Bioactive Materials 2024, 38, 321-330. [link]

Li. Z.; Duan,Y.; Zhang, F.; Luan, H.; Shen, W.; Yu, Y.; Xian, N.; Guo, Z.; Zhang, E.; Yin, L.; Fang, R.; Gao, W.; Zhang, L.*; Wang, J. "Biohybrid microrobots regulate colonic cytokine levels and modulate epithelium layer restoration in inflammatory bowel disease", Science Robotics 2024, 9, eadl2007. [link] [highlight]

Krishnan, N.; Fang, R.; Zhang, L.* "Rapid functionalization of cell membrane-coated nanoparticles using a modular approach", Clinical and Translational Medicine 2024, 14, e1721. [link]

Kai, M.; Shen, W.; Yu, Y.; Wang, D.; Zhang, J.; Wang, S.; Fang, R.; Gao, W.; Zhang, L.* "Dual-modal cellular nanoparticles for continuous neurotoxin detoxification", Nano Letters 2024, 24, 7515-7523. [link]

Zhang, F.; Guo, Z.; Li, Z.; Luan, H.; Yu, Y.; Zhu, A.; Ding, S.; Gao, W.; Fang, R.; Zhang, L.*, Wang, J. "Biohybrid microrobots deliver drug-loaded nanoparticles to hinder the progression of lung metastasis", Science Advances 2024, 10, eadn6157. [link]

Sun, L.; Wang, D.; Feng, K.; Zhang, J.; Gao, W.; Zhang, L.* "Cell membrane-coated nanoparticles for targeting carcinogenic bacteria", Advanced Drug Delivery Reviews 2024, 209, 115320. [link]

Yu, Y.; Peng, Y.; Shen, W.; Zhou, Z.; Kai, M.; Gao, W.; Zhang, L.* "Hybrid cell membrane-coated nanoparticles for biomedical applications", Small Structures 2024, 5, 2300473. [link]

Sun, L.; Yu, Y.; Peng, Y.; Wang, D.; Wang, S.; Noh, I.; Fang, R.; Gao, W.; Zhang, L.* "Platelet membrane-derived nanodiscs for neutralization of endogenous autoantibodies and exogenous pathogens", Small 2024, 20, 2308327. [link]

Wang, S.; Wang, D.; Shen, W.; Kai, M.; Yu, Y.; Peng, Y.; Xian, N.; Fang, R.; Gao, W.; Zhang, L.* "Protein-loaded cellular nanosponges for dual-biomimicry neurotoxin countermeasure", Small 2024, 20, 2309635. [link]

Krishnan, N.; Jiang, Y.; Zhou, J.; Mohapatra, A.; Peng, F.; Duan, Y.; Holay, M.; Chekuri, S.; Guo, Z.; Gao, W.; Fang, R.; Zhang, L.* "A modular approach to enhancing cell membrane-coated nanoparticle functionality using genetic engineering", Nature Nanotechnology 2024, 19, 345-353. [link]

Zhang, F.; Li, Z.; Chen, C.; Luan, H.; Fang, R.; Zhang, L.*; Wang, J. "Biohybrid microalgae robots: Design, fabrication, materials and applications", Advanced Materials 2024, 36, 2303714. [link]

Duan, Y.; Zhou, J.; Zhou, Z.; Zhang, E. Yu, Y.; Krishnan, N.; Silva-Ayala, D.; Fang, R.; Griffiths, A.; Gao, W.; Zhang, L.* "Extending the in vivo residence time of macrophage membrane-coated nanoparticles through genetic modification", Small 2023, 19, 2305551. [link]

Fang, R.; Zhang, L.* "Biohybrid nanoparticles for treating arthritis", Nature Nanotechnology 2023, 18, 1387-1388. [link]

Ai, X.; Wang, D.; Noh, I.; Duan, Y.; Zhou, Z.; Mukundan, N.; Fang, R.; Gao, W.; Zhang, L.* "Glycan-modified cellular nanosponges for enhanced neutralization of botulinum toxin", Biomaterials 2023, 302, 122330. [link]

Guo, Z.; Noh, I.; Zhu, A.; Yu, Y.; Gao, W.; Fang, R.; Zhang, L.* "Cancer cell membrane nanodiscs for antitumor vaccination", Nano Letters 2023, 23, 7941-7949. [link]

Kai, M.; Wang, S.; Gao, W.; Zhang, L.* "Designs of metal-organic framework nanoparticles for protein delivery", Journal of Controlled Release 2023, 361, 178-190. [link]

Duan, Y.; Zhang, E.; Fang, R.; Gao, W.; Zhang, L.* "Capsulated cellular nanosponges for the treatment of experimental inflammatory bowel disease", ACS Nano 2023, 17, 15893-15904. [link]

Guo, Z.; Zhou, J.; Yu, Y.; Krishnan, N.; Noh, I.; Zhu, A.; Borum, R. Gao, W.; Fang, R.; Zhang, L.* "Immunostimulatory DNA hydrogel enhances protective efficacy of nanotoxoids against bacterial infection", Advanced Materials 2023, 35, 2211717. [link]

Pihl, J.; Clausen, T.; Zhou, J.; Krishnan, N.; Madsen, M.; Gustavesson, T.; Dagil, R.; Daugaard, M.; Choudhary, S.; Foged, C.; Esko, J.; Zhang, L.; Fang, R.; Salanti, A. "A malaria biomimetic for tumor targeted drug delivery", ACS Nano 2023, 17, 13500-13509. [link]

Zhou, Z.; Kai, M.; Wang, S.; Wang, D.; Peng, Y.; Yu, Y.; Gao, W.; Zhang, L.* "Emerging nanoparticle designs against bacterial infections", WIREs Nanomedicine & Nanobiotechnology 2023, 15, e1881. [link]

Krishnan, N.; Fang, R.; Zhang, L.* "Cell membrane-coated nanoparticles for the treatment of cancer", Clinical and Translational Medicine 2023, 13, e1285. [link]

Mundaca-Uribe, R.; Holay, M.; Abbas, A.; Askarinam, N.; Sage-Sepulveda, J.; Kubiatowicz, L; Fang, R.; Zhang, L.*, Wang, J. "A microstirring oral pill for improving the glucose-lowering effect of metformin", ACS Nano 2023, 17, 9272-9279. [link]

Guo, Z.; Zhu, A.; Fang, R.; Zhang, L.* "Recent developments in nanoparticle-based photo-immunotherapy for cancer treatment", Small Methods 2023, 7, 2300252. [link]

Sun, L.; Wang, D.; Noh, I.; Fang, R.; Gao, W.; Zhang, L.* "Synthesis of erythrocyte nanodiscs for bacterial toxin neutralization", Angewandte Chemie International Edition 2023, 62, e202301566. [link] [journal cover]

Krishnan, N.; Peng, F.; Mohapatra, A.; Fang, R.; Zhang, L.* "Genetically engineered cellular nanoparticles for biomedical application", Biomaterials 2023, 296, 122065. [link]

Wang, S.; Wang, D.; Kai, M.; Shen, W.; Sun, L.; Gao, W.; Zhang, L.* "Design strategies for cellular nanosponges as medical countermeasures", BME Frontiers 2023, 4, 0018. [link]

Fang, R.; Zhang, L.* "Inhalable mRNA nanoparticles", Nature Materials 2023, 22, 278-279. [link]

Duan, Y.; Wang, D.; Wang, S.; Zhou, Z.; Komarla A.; Zhou, J.; Zhang, Q.; Ai, X.; Gao, W.; Zhang, L.* "Cell membrane-coated nanoparticles and their biomedical applications", Encyclopedia of Nanomaterials 2023, 3, 519-542. [link]

Bjanes, E.; Zhou, J.; Qayum, T.; Krishnan, N.; Zurich, R.; Menon, N.; Hoffman, A.; Fang, R.; Zhang, L.*, Nizet, V. "Outer membrane vesicle-coated nanoparticle vaccine protects against Acinetobacter baumannii pneumonia and sepsis", Advanced NanoBiomed Research 2023, 3, 2200130. [link]

Noh, I.; Guo, Z.; Zhou, J.; Gao, W.; Fang, R.; Zhang, L.* "Cellular nanodiscs made from bacterial outer membrane as a platform for antibacterial vaccination", ACS Nano 2023, 17, 1120-1127. [link]

Fang, R.; Gao, W.; Zhang, L.* "Targeting drugs to tumours using cell membrane-coated nanoparticles", Nature Reviews Clinical Oncology 2023, 20, 33-48. [link] [journal cover]

Zhang, F.; Li, Z.; Duan, Y.; Luan, H.; Yin, L.; Guo, Z.; Chen, C.; Xu, M.; Gao, W.; Fang, R.; Zhang, L.*, Wang, J. "Extremophile-based biohybrid micromotors for biomedical operations in harsh environments", Science Advances 2022, 8, eade6455. [link]

Kubiatowicz, L.; Mohapatra, A.; Krishnan, N.; Fang, R.; Zhang, L.* "mRNA nanomedicine: design and recent applications", Exploration 2022, 2, 20210217. [link]

Holay, M.; Krishnan, N.; Zhou, J.; Duan, Y.; Guo, Z.; Gao, W.; Fang, R.; Zhang, L.* "Single low-dose nanovaccine for long-term protection against anthrax toxins", Nano Letters 2022, 22, 9672-9678. [link]

Wang, D.; Ai, X.; Duan, Y.; Xian, N.; Fang, R.; Gao, W.; Zhang, L.* "Neuronal cellular nanosponges for effective detoxification of neurotoxins", ACS Nano 2022, 16, 19145-19154. [link]

Zhang, F.; Zhuang, J.; Li, Z.; Gong, H.; Bsteban-Fernandez de Avila, B.; Duan, Y.; Zhang, Q.; Zhou, J.; Yin, L.; Karshalev, E.; Gao, W.; Nizet, V.; Fang, R.; Zhang, L.*; Wang, J. "Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia", Nature Materials 2022, 21, 1324-1332. [link]

Vargas, E.; Zhang, F.; Hassine, A.; Montiel, V.; Mundaca-Uribe, R.; Nandhakumar, P.; He, P.; Guo, Z.; Zhou, Z.; Fang, R.; Gao, W.; Zhang, L.*; Wang, J. "Using cell membrane as recognition layers to construct ultrasensitive and selective bioelectronic affinity sensors", Journal of the American Chemical Society 2022, 144, 17700-17708. [link]

Zhang, F.; Li, Z.; Duan, Y.; Abbas, A.; Mundaca-Uribe, R.; Yin, L.; Luan, H.; Gao, W.; Fang, R.; Zhang, L.*, Wang, J. "Gastrointestinal tract drug delivery using algae motors embedded in a degradable capsule", Science Robotics 2022, 7, eabo4160. [link]

Zhou, J.; Ventura, C.; Yu, Y.; Gao, W.; Fang, R.; Zhang, L.* "Biomimetic neutrophil nanotoxoids elicit potent immunity against Acinetobacter baumannii in multiple models of infection", Nano Letters 2022, 22, 7057-7065. [link]

Zhou, J.; Krishnan, N.; Guo, Z.; Ventura, C.; Holay, M.; Zhang, Q.; Wei, X.; Gao, W.; Fang, R.; Zhang, L.* "Nanotoxoid vaccination protects against opportunistic bacterial infections arising from immunodeficiency", Science Advances 2022, 8, eabq5492. [link]

Zhou, J.; Miyamoto, Y.; Ihara, S.; Kroll, A.; Nieskens, N.; Tran, V.; Hanson, E.; Fang, R.; Zhang, L., Eckmann, L. "Co-delivery of antigens and adjuvant in polymeric nanoparticles coated with native parasite membranes induces protective mucosal immunity against Giardia lamblia", Journal of Infectious Diseases 2022, 226, 319-323. [link]

Wang, S.; Kai, M.; Duan, Y.; Zhou, Z.; Fang, R.; Gao, W.; Zhang, L.* "Membrane cholesterol depletion enhances enzymatic activity of cell-membrane-coated metal-organic-framework nanoparticles", Angewandte Chemie International Edition 2022, 61, e202203115. [link] [journal cover]

Krishnan, N.; Kubiatowicz, L.; Holay, M.; Zhou, J.; Fang, R.; Zhang, L.* "Bacterial membrane vesicles for vaccine applications", Advanced Drug Delivery Reviews 2022, 185, 114294. [link]

Holay, M.; Zhou, J.; Park, J.; Landa, I.; Ventura, C.; Gao, W.; Fang, R.; Zhang, L.* "Organotropic targeting of biomimetic nanoparticles to treat lung diseases", Bioconjugate Chemistry 2022, 33, 586-593. [link]

Wang, D.; Wang, S.; Zhou, Z.; Bai, D.; Zhang Q.; Gao, W.; Zhang, L.* "White blood cell membrane-coated nanoparticles: recent development and medical applications", Advanced Healthcare Materials 2022, 11, 2101349. [link]

Johnson, D.; Zhou, J.; Kroll, A.; Fang, R.; Yan, M.; Xiao, C.; Chen, X.; Kline, J.; Zhang, L.; Zhang, D-E. "Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy", Leukemia 2022, 36, 994-1005. [link]

Wang, S.; Wang, D.; Duan, Y.; Zhou, Z.; Gao, W.; Zhang, L.* "Cellular nanosponges for biological neutralization", Advanced Materials 2022, 34, 2107719. [link]

Gu, Y.; Wang, C.; Kim, N.; Zhang, J.; Wang, T. M.; Stowe, J.; Nasiri, R.; Li, J.; Zhang, D.; Yang, A.; Hsu, L.; Dai, X.; Mu, J.; Lawence, N.; Liu, Z.; Lin, M.; Li, W.; Wang, C.; Gong, H.; Chen, Y.; Lei, Y.; Hu, H.; Li, Y.; Zhang, L.; Huang, Z; Zhang, X.; Ahadian, S.; Banik, P.; Zhang, L.; Jiang, X.; Burke, P.; Khademhosseini, A.; McCulloch, A.; Xu, S. "Three-dimensional transistor arrays for intra- and inter-cellular recording", Nature Nanotechnology 2022, 17, 292-300. [link]

Zhang, F.; Mundaca-Uribe, R.; Askarinam, N.; Li, Z.; Gao, W.; Zhang, L.*, Wang, J. "Biomembrane-functionalized micromotors: biocompatible active devices for diverse biomedical applications", Advanced Materials 2022, 34, 2107177. [link]

Zhou, J.; Ventura, C.; Fang, R.; Zhang, L.* "Nanodelivery of STING agonists against cancer and infectious diseases", Molecular Aspects of Medicine 2022, 83, 101007. [link]

Park, J. H.; Mohapatra, A.; Zhou, J.; Holay, M.; Krishnan, N.; Gao, W.; Fang, R.; Zhang, L.* "Virus-mimicking cell membrane-coated nanoparticles for cytosolic delivery of mRNA", Angewandte Chemie International Edition 2022, 61, e202113671. [link]

Zhou, J.; Karshalev, E.; Mundaca-Uribe, R.; Bsteban-Fernandez de Avila, B.; Krishnan, N.; Xiao, C.; Ventura C.; Gong, H.; Zhang, Q.; Gao, W.; Fang, R.; Wang, J.; Zhang L.* "Physical disruption of solid tumors by immunostimulatory microrobots enhances antitumor immunity", Advanced Materials 2021, 33, 2103505. [link]

Duan, Y.; Wang, S.; Zhang, Q.; Gao, W.; Zhang, L.* "Nanoparticle approaches against SARS-CoV-2 infection", Current Opinion in Solid State & Materials Science 2021, 25, 100964. [link]

Krishnan, N.; Fang, R.; Zhang, L.* "Engineering of stimuli-responsive self-assembled biomimetic nanoparticles", Advanced Drug Delivery Reviews 2021, 179, 114006. [link]

Ai, X.; Wang, D.; Honko, A.; Duan, Y.; Gavrish, I.; Fang, R.; Griffiths, A.; Gao, W.; Zhang, L.* "Surface glycan modification of cellular nanosponges to promote SARS-CoV-2 inhibition", Journal of the American Chemical Society 2021, 143, 17615-17621. [link]

Campbell, G.; Zhuang, J.; Zhang, G.; Landa, I.; Kubiatowicz, L.; Dehaini, D.; Fang, R.; Zhang, L.; Spector, S. "CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kills HIV-1 infected cells", Theranostics 2021, 11, 9009-9021. [link]

Kim, J-K.; Uchiyama, S.; Gong, H.; Zhang, L.; Nizet, V. "Engineered biomimetic platelet membrane-coated nanoparticles block Staphylococcus aureus cytotoxicity and protect against lethal systemic infection", Engineering 2021, 7, 1149-1156. [link]

Guo, Z.; Kubiatowicz, L.; Fang, R.; Zhang, L.* "Nanotoxoids: biomimetic nanoparticle vaccines against infections", Advanced Therapeutics 2021, 4, 2100072. [link]

Zhang, F.; Li, Z.; Yin, L.; Zhang, Q.; Askarinam, N.; Mundaca-Uribe, R.; Tehrani, F.; Karshalev E.; Gao, W.; Zhang, L.*; Wang, J. "ACE2 receptor-modified algae-based microrobot for removal of SARS-CoV-2 in wastewater", Journal of the American Chemical Society 2021, 143, 12194-12201. [link] [journal cover]

Zhang, Q.; Zhou, J.; Zhou, J.; Fang, R.; Gao, W.; Zhang, L.* "Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis", Nature Communications 2021, 12, 4136. [link]

Mundaca-Uribe, R.; Karshalev, E.; Bsteban-Fernandez de Avila, B.; Wei, X.; Nguyen, B.; Litvan, I.; Fang, R.; Zhang, L.*; Wang, J. "A microstirring pill enhances bioavailability of orally administered drugs", Advanced Science 2021, 8, 2100389. [link]

Park, J. H.; Jiang, Y.; Zhou, J.; Gong, H.; Mohapatra, A.; Heo, J.; Gao, W.; Fang, R.; Zhang, L.* "Genetically engineered cell membrane-coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs", Science Advances 2021, 7, eabf7820. [link]

Miyamoto, Y.; Aggarwal, S.; Celaje, J.; Ihara, S.; Ang, J.; Land, K.; Wrischnik, L.; Zhang, L.; Fokin, V.; Eckmann, L. "Gold(I) phosphine derivatives with improved selectively as topically active drug leads to overcome 5-nitroheterocyclic drug resistance in Trichomonas vaginalis", Journal Medicinal Chemistry 2021, 64, 6608-6620. [link]

Holay, M.; Guo, Z.; Pihl, J.; Heo, J.; Park, J.; Fang, R.; Zhang, L.* "Bacteria-inspired nanomedicine", ACS Applied Bio Materials 2021, 4, 3830-3848. [link]

Ai, X.; Wang, S.; Duan, Y.; Zhang, Q.; Chen, M.; Gao, W.; Zhang, L.* "Emerging approaches to functionalizing cell membrane-coated nanoparticles", Biochemistry 2021, 60, 941-955. [link]

Bahmani, B.; Gong, H.; Luk, B.; Haushalter, K.; DeTeresa, E.; Previti, M.; Zhou, J.; Gao, W.; Bui, J.; Zhang, L.; Fang, R.; Zhang, J. "Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors", Nature Communications 2021, 12, 1999. [link]

Gong, H.; Zhang, Q.; Komarla, A.; Wang, S.; Duan, Y.; Zhou, Z.; Chen, F.; Fang, R.; Xu, S.; Gao, W.; Zhang, L.* "Nanomaterial biointerfacing via mitochondrial membrane coating for targeted detoxification and molecular detection", Nano Letters 2021, 21, 2603-2609. [link]

Zhou, J.; Krishnan, N; Jiang, Y.; Fang, R.; Zhang, L.* "Nanotechnology for virus treatment", Nano Today 2021, 36, 101031. [link]

Ai, X.; Duan, Y.; Zhang, Q.; Sun, D.; Fang, R.; Liu-Bryan, R.; Gao, W.; Zhang, L.* "Cartilage-targeting ultrasmall lipid-polymer hybrid nanoparticles for the prevention of cartilage degradation", Bioengineering & Translational Medicine 2021, 6, e10187. [link] [journal cover]

Gao, W.; Zhang, L.* "Nanomaterials arising amid antibiotic resistance", Nature Reviews Microbiology 2021, 19, 5-6. [link]

Wang, S.; Duan, Y.; Zhang, Q.; Komarla, A.; Gong, H.; Gao, W.; Zhang, L.* "Drug targeting via platelet membrane-coated nanoparticles", Small Structures 2020, 1, 2000018. [link]

Mundaca-Uribe, R.; Bsteban-Fernandez de Avila, B.; Holay, M.; Venugopalan, P.; Nguyen, B.; Zhou, J.; Abbas, A.; Fang, R.; Zhang, L.*; Wang, J. "Zinc microrocket pills: fabrication and characterization towards active oral delivery", Advanced Healthcare Materials 2020, 9, 2000900. [link]

Zhang, G.; Campbell, G.; Zhang, Q.; Maule, E.; Hanna J.; Gao, W.; Zhang, L.; Spector, S. "CD4+ T cell mimicking nanoparticles broadly neutralize HIV-1 and suppress viral replication through autophagy", mBio 2020, 11, e00903-20. [link]

Huang, N.; Fan, X.; Rivera, K.; Nguyen, T.; Zhou, J.; Luo, Y.; Gao, J.; Fang, R.; Yan, Z.; Chen, Z.; Zhang, L.; Zhong, S. "Natural display of nuclear-encoded RNA on the cell surface and its impact on cell interaction", Genome Biology, 2020, 21, 225. [link]

Lipomi, D.; Fenning, D.; Ong, S. P.; Shah, N.; Tao, A.; Zhang, L. "Exploring frontiers in research and teaching: NanoEngineering and Chemical Engineering at UC San Diego", ACS Nano 2020, 14, 9203-9216. [link]

Jiang, Y.; Krishnan, N.; Zhou, J.; Chekuri, S.; Wei, X.; Kroll, A.; Yu, C.; Gao, W.; Fang, R.; Zhang, L.* "Engineered cell membrane-coated nanoparticles directly present tumor antigens to promote anticancer immunity",  Advanced Materials 2020, 32, 2001808. [link]

Zhang, Q.; Honko, A.; Zhou, J.; Downs, S.; Henao Vasquez, J.; Fang, R.; Gao, W.; Griffiths, A.; Zhang, L.* "Cellular nanosponges inhibit SARS-CoV-2 infectivity", Nano Letters 2020, 20, 5570-5574. [link]
Highlighted: Science Translational Medicine 2020, 12, eabd3078 (Editor's Choice). [link]
                    Forbes June 17, 2020. [link]

Bsteban-Fernandez de Avila, B., Lopez-Ramirez, M.; Mundaca-Uribe, R.; Wei, X.; Ramirez-Herrera, D.; Karshalev, E.; Nguyen, B.; Fang, R.; Zhang, L.*, Wang, J. "Multi-compartment tubular micromotors towards enhanced localized active delivery", Advanced Materials 2020, 32, 2000091. [link]

Zhang, Q.; Fang, R.; Gao, W.; Zhang, L.* "A biomimetic nanoparticle to 'lure and kill' phospholipase A2", Angewandte Chemie International Edition 2020, 59, 10461-10465. [link]

Tang, S.; Zhang, F.; Gong, H.; Wei, F.; Zhuang, J.; Karshalev, E.; Bsteban-Fernandez de Avila, B., Huang, C.; Hu, Z; Zhou, Z.; Li, Z; Lu, Y.; Dong, H.; Fang, R.; Zhang, X.; Zhang, L.*, Wang, J. "Enzyme-powered Janus platelet micromotors for targeted therapeutic delivery", Science Robotics 2020, 5, eaba6137. [link]
Highlighted: Science Robotics 2020, 5, eabc6582. [link]

Jiang, Y.; Krishnan, N.; Heo, J.; Fang, R.; Zhang, L.* "Nanoparticle-hydrogel superstructures for biomedical applications", Journal of Controlled Release 2020, 324, 505-521. [link]

Zhang, Q.; Gong, H.; Gao, W.; Zhang, L.* "Recent progress in capturing and neutralizing inflammatory cytokines", CCS Chemistry 2020, 2, 376-389. [link]

Zhuang, J.; Duan, Y.; Zhang, Q.; Gao, W.; Li, S.; Fang, R.; Zhang, L.* "Multimodal enzyme delivery and therapy enabled by cell membrane-coated metal-organic framework nanoparticles", Nano Letters 2020, 20, 4051-4058. [link]

Zhou, J.; Kroll, A.; Holay, M.; Fang, R.; Zhang, L.* "Biomimetic nanotechnology toward personalized vaccines", Advanced Materials 2020, 32, 1901255. [link]

Zhuang, J.; Gong, H.; Zhou, J.; Zhang, Q.; Gao W.; Fang, R.; Zhang, L.* "Targeted gene silencing in vivo by platelet membrane-coated metal-organic framework nanoparticles", Science Advances 2020, 6, eaaz6108. [link]

Park, J. H.; Dehaini, D.; Zhou, J.; Holay, M.; Fang, R.; Zhang, L.* "Biomimetic nanoparticle technology for cardiovascular disease detection and treatment", Nanoscale Horizons 2020, 5, 25-42. [link]

Zhang, Y.; Miyamoto, Y.; Ihara, S.; Yang, J.; Zuill, D.; Angsantikul, P.; Zhang, Q.; Gao, W.; Zhang, L.*, Eckmann, L. "Composite thermoresponsive hydrogel with auranofin-loaded nanoparticles for topical treatment of vaginal trichomonad infection", Advanced Therapeutics 2019, 2, 1900157. [link]

Wierzbicki, I.; Campeau, A.; Dehaini, D.; Holay, M.; Wei, X.; Greene, T.; Ying, M.; Sands, J.; Lamsa, A.; Zuniga, E.; Pogliano, K.; Fang, R.; LaRock, C.; Zhang, L.; Gonzalez, D. "Group A Streptococcal S protein utilizes red blood cells as immune camouflage and is a critical determinant for immune evasion", Cell Reports 2019, 29, 2979-2989. [link]

Karshalev, E.; Zhang, Y.; Bsteban-Fernandez de Avila, B.; Beltran-Gastelum, M.; Chen, Y.; Mundaca-Uribe, R.; Zhang, F.; Nguyen, B.; Tong, Y.; Fang, R.; Zhang, L.*, Wang, J. "Micromotors for active delivery of minerals toward the treatment of iron deficiency anemia", Nano Letters 2019, 19, 7816-7826. [link]

Koo, J.; Escajadillo, T.; Zhang, L.; Nizet, V.; Lawrence, S. M. "Erythrocyte-coated nanoparticles block cytotoxic effects of group B streptococcus beta-hemolysin/cytolysin", Frontiers in Pediatrics 2019, 7, 410. [link]

Zhang, F.; Zhuang, J.; Bsteban-Fernandez de Avila, B.; Tang, S.; Zhang, Q.; Fang, R.; Zhang, L.*; Wang, J. "A nanomotor-based active delivery system for intracellular oxygen transport", ACS Nano 2019, 13, 11996-12005. [link]

Zhuang, J.; Holay, M.; Park, J. H.; Fang, R.; Zhang, J.; Zhang, L.* "Nanoparticle delivery of immunostimulatory agents for cancer immunotherapy", Theranostics 2019, 9, 7826-7848. [link]

Fang, R.; Zhang, L.* "Biomimetic nanosponges as a broad-spectrum countermeasure to biological threats", HDIAC Journal, 2019, 6(3), 14-19. [link] [journal cover]

Zhang, Y.; Chen, Y.; Lo, C.; Zhuang, J.; Angsantikul, P.; Zhang, Q.; Wei, X.; Zhou, Z.; Obonyo, M.; Fang, R.; Gao, W.; Zhang, L.* "Inhibition of pathogen adhesion by bacterial outer membrane-coated nanoparticles", Angewandte Chemie International Edition 2019, 58, 11404-11408. [link]

Kumar, S.; Han, J.; Michael, I.; Ki, D.; Sunkara, V.; Park, J.; Gautam, S.; Ha, H. K.; Zhang, L.; Cho, Y. "Human platelet membrane functionalized microchips with plasmonic codes for cancer detection", Advanced Functional Materials 2019, 29, 1902669. [link] [journal cover]

Wei, X.; Ran, D.; Campeau, A.; Xiao, C.; Zhou, J.; Dehaini, D.; Jiang, Y.; Zhang, Q.; Gao, W.; Gonzalez, D.; Fang, R.; Zhang, L.* "Multiantigenic nanotoxoid for antivirulence vaccination against antibiotic-resistant gram-negative bacteria", Nano Letters 2019, 19, 4760-4769. [link]

Leong, H. S. et al. "On the issue of transparency and reproducibility in nanomedicine", Nature Nanotechnology 2019, 14, 629-635. [link]

Zhang, F.; Mundaca-Uribe, R.; Gong, H.; Bsteban-Fernandez de Avila, B.; Beltran-Gastelum, M.; Karshalev, E.; Nourhani, A.; Tong, Y.; Nguyen, B.; Gallot, M.; Zhang, Y.; Zhang, L.*, Wang, J. "A macrophage-magnesium hybrid biomotor: Fabrication and characterization", Advanced Materials 2019, 31, 1901828. [link]

Chen, Y.; Zhang, Y.; Zhuang, J.; Lee, J. H.; Wang, L.; Fang, R.; Gao, W.; Zhang, L.* "Cell membrane-cloaked oil nanosponges enable dual-modal detoxification", ACS Nano 2019, 13, 7209-7215. [link]

Chai, Z.; Ran, D.; Lu, L.; Zhan, C.; Ruan, H.; Hu, X.; Xie, C.; Jiang, K.; Li, J.; Zhou, J.; Wang, J.; Zhang, Y.; Fang, R.; Zhang, L.*, Lu, W. "Ligand-modified cell membrane enables targeted delivery of drug nanocrystals to glioma", ACS Nano 2019, 13, 5591-5601. [link]

Zhang, G.; Luk, B.; Wei, X.; Campbell, G.; Fang, R.; Zhang, L.; Spector, S. "Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides", Cell Death & Disease 2019, 10, 419. [link]

Coburn, P.; Miller, F.; LaGrow, A.; Land, C.; Mursalin, H.; Livingston, E.; Amayem, O.; Chen, Y.; Gao, W.; Zhang, L.; Callegan, M. "Disarming pore-forming toxins with biomimetic nanosponges in intraocular infections", mSphere 2019, 4, e00262-19. [link]

Gong, H.; Chen, F.; Huang, Z.; Gu, Y.; Zhang, Q.; Chen, Y.; Zhang, Y.; Zhuang, J.; Cho, Y.; Fang, R.; Gao, W.; Xu, S.; Zhang, L.* "Biomembrane-modified field effect transistors for sensitive and quantitative detection of biological toxins and pathogens", ACS Nano 2019, 13, 3714-3722. [link]

Wei, X.; Beltran-Gastelum, M.; Karshalev, E.; Bsteban-Fernandez de Avila, B.; Zhou, J.; Ran, D.; Angsantikul, P.; Fang, R.; Wang, J.; Zhang, L.* "Biomimetic micromotor enables active delivery of antigens for oral vaccination", Nano Letters 2019, 19, 1914-1921. [link]

Mitra, A.; Yan, J.; Zhang, L.; Li, S. "A small molecule Hedgehog agonist HhAg1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure", Translational Research 2019, 205, 44-50. [link]

Chen, Y.; Zhang, Y.; Chen, M.; Zhuang, J.; Fang, R.; Gao, W.; Zhang, L.* "Biomimetic nanosponges suppress the in vivo lethality induced by the whole secreted proteins of pathogenic bacteria", Small 2019, 15, 1804994. [link]

Lu, X.; Martin, A.; Angsantikul, P.; Li, J.; Soto, F.; Chen, C.; Liang, Y.; Hu, J.; Zhang, L.*, Wang, J. "Parallel label-free isolation of cancer cells using acoustic microstreaming traps", Advanced Materials Technologies 2019, 4, 1800374. [link]

Kroll, A.; Jiang, Y.; Zhou, J.; Holay, M.; Fang, R.; Zhang, L.* "Biomimetic nanoparticle vaccines for cancer therapy", Advanced Biosystems 2019, 3, 1800219. [link]

Jiang, Y.; Chekuri, S.; Fang, R.; Zhang, L.* "Engineering biological interactions on the nanoscale", Current Opinion in Biotechnology 2019, 58, 1-8. [link]

Zhang, Q.; Dehaini, D.; Zhang, Y.; Zhou, J.; Chen, X.; Zhang, L.; Fang, R.; Gao, W.; Zhang, L.* "Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis", Nature Nanotechnology 2018, 13, 1182-1190. [link]
Highlighted: Nature Nanotechnology 2018, 13, 1098-1099 (News & Views). [link]
                    Nature Reviews Rheumatology 2018, 14, 622. [link]
                    Science Translational Medicine 2018, 10, eaav0341 (Editor's Choice). [link]

Zhuang, J.; Ying, M.; Spiekermann, K.; Holay, M.; Zhang, Y.; Chen, F.; Gong, H.; Lee, J-H.; Gao, W.; Fang, R.; Zhang, L.* "Biomimetic nanoemulsions for oxygen delivery in vivo", Advanced Materials 2018, 30, 1804693. [link]

Wei, X.; Zhang, G.; Ran, D.; Krishnan, N.; Fang, R.; Gao, W.; Spector, S.; Zhang, L.* "T cell-mimicking nanoparticles can neutralize HIV infectivity", Advanced Materials 2018, 30, 1802233. [link]

Esteban-Fernandez de Avila, B.; Gao, W.; Karshalev, E.; Zhang, L.*, Wang, J. "Cell-like micromotors", Accounts of Chemical Research 2018, 51, 1901-1910. [link]

Wang, C.; Li, X.; Hu, H.; Zhang, L.; Huang, Z.; Lin, M.; Zhang, Z.; Yin, Z.; Huang, B.; Gong, H.; Bhaskaran, S.; Gu, Y.; Makihata, M.; Guo, Y.; Lei, Y.; Chen, Y.; Wang, C.; Li, Y.; Zhang, T.; Chen, Z.; Pisano, A. P.; Zhang, L.; Zhou, Q.; Xu, S. "Monitoring of the central blood pressure waveform via a conformal ultrasonic device", Nature Biomedical Engineering 2018, 2, 687-695. [link]
Highlighted: Nature Biomedical Engineering 2018, 2, 633-634 (News & Views). [link]

Luk, B.; Jiang, Y.; Copp, J.; Hu, C-M.; Krishnan, N.; Gao, W.; Li, S.; Fang, R.; Zhang, L.* "Biomimetic targeting of nanoparticles to immune cell subsets via cognate antigen interactions", Molecular Pharmaceutics 2018, 15, 3723-3728. [link]

Karshalev, E.; Esteban-Fernandez de Avila, B.; Beltran-Gastelum, M.; Angsantikul, P.; Tang, S.; Mundaca-Uribe, R.; Zhang, F.; Zhao, J.; Zhang, L.*, Wang, J. "Micromotor pills as a dynamic oral delivery platform", ACS Nano 2018, 12, 8397-8405. [link]

Zhang, G.; Luk, B.; Hamidy, M.; Zhang, L.; Spector, S. "Induction of Na+/K+-ATPase dependent form of autophagy triggers preferential cell death of human immunodeficiency type-1-infected macrophages", Autophagy 2018, 14, 1359-1375. [link]

Xia, H.; Li, X.; Gao, W.; Fu, X.; Fang, R.; Zhang, L.*, Zhang, K. "Tissue repair and regeneration with endogenous stem cells", Nature Reviews Materials 2018, 3, 174-193. [link]

Chen, Y.; Chen, M.; Zhang, Y.; Lee, J. H.; Escajadillo, T.; Gong, H.; Fang, R.; Gao, W.; Nizet, V.; Zhang, L.* "Broad-spectrum neutralization of pore-forming toxins with human erythrocyte membrane-coated nanosponges", Advanced Healthcare Materials 2018, 7, 1701366. [link] [journal cover]

Fang, R.; Zhang, L.* "Combatting infections with nanomedicine", Advanced Healthcare Materials 2018, 7, 1800392. (Editorial) [link]

Kim, T.; Zhang, Q.; Li, J.; Zhang, L. Jokerst, J. "A gold/silver hybrid nanoparticle for treatment and photoacoustic imaging of bacterial infection", ACS Nano 2018, 12, 5615-5625. [link]

Angsantikul, P.; Thamphiwatana, S.; Zhang, Q.; Spiekermann, K.; Zhuang, J.; Fang, R.; Gao, W.; Obonyo, M.; Zhang, L* "Coating nanoparticles with gastric epithelial cell membrane for targeted antibiotic delivery against Helicobacter pylori infection", Advanced Therapeutics 2018, 1, 1800016. [link]

Esteban-Fernandez de Avila, B.; Angsantikul, P.; Li, J.; Gao, W.; Zhang, L.*, Wang, J. "Micromotors go in vivo: From test tubes to live animals", Advanced Functional Materials 2018, 28, 1705640. [link]

Fang, R.; Kroll, A.; Gao, W.; Zhang, L.* "Cell membrane coating nanotechnology", Advanced Materials 2018, 30, 1706759. [link]

Esteban-Fernandez de Avila, B.; Angsantikul, P.; Ramirez-Herrera, D.; Soto, F.; Teymourian, H.; Dehaini, D.; Chen, Y.; Zhang, L.*, Wang, J. "Hybrid-biomembrane functionalized nanorobots for concurrent removal of pathogenic bacteria and toxins", Science Robotics 2018, 3, eaat0485. [link]

Ying, M.; Zhuang, J.; Wei, X.; Zhang, X.; Zhang, Y.; Jiang, Y.; Dehaini, D.; Chen, M.; Gu, S.; Gao, W.; Lu, W.; Fang, R.; Zhang, L.* "Remote-loaded platelet vesicles for disease-targeted delivery of therapeutics", Advanced Functional Materials 2018, 28, 1801032. [link]

Lapek, J.; Mills, R.; Wozniak, J.; Campeau, A.; Fang, R.; Wei, X.; van de Groep, K.; Perez-Lopez, A.; van Sorge, N.; Raffatellu, M.; Knight, R.; Zhang, L.; Gonzalez, D. "Defining host responses during systemic bacterial infection through construction of a murine organ proteome atlas", Cell Systems 2018, 6, 579-592. [link]

Fang, R.; Zhang, L.* "Optical detection of abnormal skin scarring", Nature Biomedical Engineering 2018, 2, 201-202. [link]

Jiang, Y.; Fang, R.; Zhang, L.* "Biomimetic nanosponges for treating antibody-mediated autoimmune diseases", Bioconjugate Chemistry 2018, 29, 870-877. [link]

Angsantikul, P.; Fang, R.; Zhang, L.* "Toxoid vaccination against bacterial infection using cell membrane-coated nanoparticles", Bioconjugate Chemistry 2018, 29, 604-612. [link]

Gao, W.; Chen, Y.; Zhang, Y.; Zhang, Q.; Zhang, L.* "Nanoparticle-based local antimicrobial drug delivery", Advanced Drug Delivery Reviews 2018, 127, 46-57. [link]

Hansen-Bruhn, M.; Esteban-Fernandez de Avila, B.; Beltran-Gastelum, M.; Zhao, J.; Ramirez-Herrera, D.; Angsantikul, P.; Gothelf, K. V.; Zhang, L.*, Wang, J. "Active intracellular delivery of Cas9-sgRNA complex using ultrasound-propelled nanomotors", Angewandte Chemie International Edition 2018, 57, 2657-2661. [link] [journal cover]

Das, S.; Angsantikul, P.; Le, C.; Bao, D.; Miyamoto, Y.; Gao, W.; Zhang, L.*, Eckmann, L. "Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera", PLOS Neglected Tropical Diseases 2018, 12, e0006266. [link]

Gao, W.; Esteban-Fernandez de Avila, B.; Zhang, L.*, Wang, J. "Targeting and isolation of cancer cells using micro/nanomotors", Advanced Drug Delivery Reviews 2018, 125, 94-101. [link]

Wei, X.; Ying, M.; Dehaini, D.; Su, Y.; Kroll, A.; Zhou, J.; Gao, W.; Fang, R.; Chien, S.; Zhang, L.* "Nanoparticle functionalization with platelet membrane enables multi-factored biological targeting and detection of atherosclerosis", ACS Nano 2018, 12, 109-116. [link]

Chen, C.; Chang, X.; Angsantikul, P.; Li, J.; Esteban-Fernandez de Avila, B.; Karshalev, E.; Liu, W.; Mou, F.; He, S.; Castillo, R.; Liang, Y.; Guan, J.; Zhang, L.*; Wang, J. "Chemotactic guidance of synthetic organic/inorganic payloads functionalized sperm micromotors", Advanced Biosystems 2018, 2, 1700160. [link]

Li, J.; Angsantikul, P.; Liu, W.; Esteban-Fernandez de Avila, B.; Chang, X.; Sandraz, E.; Liang, Y.; Zhu, S.; Zhang, Y.; Chen, C.; Gao, W.; Zhang, L.*, Wang, J. "Biomimetic platelet-camouflaged nanorobots for binding and isolation of biological threats", Advanced Materials 2018, 30, 1704800. [link]

Zhang, Y.; Gao, W.; Chen, Y.; Escajadillo, T.; Ungerleider, J.; Fang, R.; Christman, K.; Nizet, V.; Zhang, L.* "Self-assembled colloidal gel using cell membrane-coated nanosponges as building blocks", ACS Nano 2017, 11, 11923-11930. [link]

Lapek, J.; Fang, R.; Wei, X.; Li, P.; Wang, B.; Zhang, L.*; Gonzalez, D. "Biomimetic virulomics for capture and identification of cell-type specific effector proteins", ACS Nano 2017, 11, 11831-11838. [link]
Highlighted: ACS Nano 2017, 11, 11768-11772. [link]

Kroll, A.; Fang, R.; Jiang, Y.; Zhou, J.; Wei, X.; Yu, C-L.; Gao, J.; Luk, B.; Dehaini, D.; Gao, W.; Zhang, L.* "Nanoparticulate delivery of cancer cell membrane elicits multi-antigenic antitumor immunity",
Advanced Materials 2017, 29, 1703969. [link]
Highlighted: Science Translational Medicine 2017, 9(417), eaar2438. [link]

Uygun, M.; Jurado-Sanchez, B.; Uygun, D. A.; Singh, V. V.; Zhang, L.*, Wang, J. "Ultrasound-propelled nanowire motors enhance asparaginase enzymatic activity against cancer cells", Nanoscale 2017, 9, 18423-18429. [link]

LaGrow, A.; Coburn, P.; Miller, F.; Land, C.; Parkunan, S. M.; Luk, B.; Gao, W.; Zhang, L.; Callegan, M. "A novel biomimetic nanosponge protects the retina from the Enterococcus faecalis cytolysin", mSphere 2017, 2, e00335-17. [link]

Zhang, X.; Angsantikul, P.; Ying, M.; Zhuang, J.; Zhang, Q.; Wei, X.; Jiang, Y.; Zhang, Y.; Dehaini, D.; Chen, M.; Chen, Y.; Gao, W.; Fang, R.; Zhang, L.* "Remote loading of small molecule therapeutics into cholesterol-enriched cell membrane-derived vesicles", Angewandte Chemie International Edition 2017, 56, 14075-14079. [link]

Thamphiwatana, S.; Angsantikul, P.; Escajadillo, T.; Zhang, Q.; Olsan, J.; Luk, B.; Zhang, S.; Fang, R.; Gao, W.; Nizet, V.; Zhang, L.* "Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management", Proceedings of the National Academy of Sciences 2017,114, 11488-11493. [link]

Chai, Z.; Hu, X.; Wei, X.; Zhan, C.; Lu, L.; Jiang, K.; Su, B.; Ruan, H.; Ran, D.; Fang, R.; Zhang, L.*; Lu, W. "A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin- derived peptide for brain-targeted drug delivery", Journal of Controlled Release 2017, 264, 102-111. [link]

Chen, M.; Zhang, Y.; Zhang, L.* "Fabrication and characterization of a 3D bioprinted nanoparticle-hydrogel hybrid device for biomimetic detoxification", Nanoscale 2017, 9, 14506-14511. [link]

Zhang, Y.; Zhang, J.; Chen, W.; Angsantikul, P.; Spiekermann, K.; Fang, R.; Gao, W.; Zhang, L.* "Erythrocyte membrane-coated nanogel for combinatorial antivirulence and responsive antimicrobial delivery against Staphylococcus aureus infection", Journal of Controlled Release 2017, 263, 185-191. [link]

Zhuang, J.; Fang, R.; Zhang, L.* "Preparation of particulate polymeric therapeutics for medical applications",  Small Methods 2017, 1, 1700147. [link]

Wei, X.; Gao, J.; Wang, F.; Ying, M.; Angsantikul, P.; Kroll, A.; Zhou, J.; Gao, W.; Lu, W.; Fang, R.; Zhang, L.* "In situ capture of bacterial toxins for antivirulence vaccination", Advanced Materials 2017, 29, 1701644. [link]

Esteban-Fernandez de Avila, B.; Angsantikul, P.; Li, J.; Lopez-Ramirez, M.; Ramirez-Herrera, D.; Thamphiwatana, S.; Chen, C.; Delezuk, J.; Ramez, V.; Zhang, L.*; Wang, J. "Micromotor-enabled active drug delivery for in vivo treatment of stomach infection", Nature Communications 2017, 8, 272. [link]

Escajadillo, T.; Olson, J.; Luk, B.; Zhang, L.*; Nizet, V. "A red blood cell-camouflaged nanoparticle counteracts streptolysin O-mediated virulence phenotypes of invasive group A Streptococcus", Frontiers in Pharmacology 2017, 8, 477. [link]

Esteban-Fernandez de Avila, B.; Ramirez-Herrera, D. E.; Campuzano, S.; Angsantikul, P.; Zhang, L.*, Wang, J. "Nanomotor-enabled pH-responsive intracellular delivery of caspase-3: Towards rapid cell apoptosis", ACS Nano 2017, 11, 5367-5374. [link]

Huang, Q.; Lee, J.; Arce, F. T.; Yoon, I.; Angsantikul, P.; Liu, J.; Shi, Y.; Villanueva, J.; Thamphiwatana, S.; Ma, X.; Zhang, L.; Chen, S.; Lal, R.; Sirbuly, D. "Nanofiber optic force transducers with sub-piconewton resolution via near-field plasmon-dielectric interactions", Nature Photonics 2017, 11, 352-357. [link]

Dehaini, D.; Wei, X.; Fang, R.; Masson, S.; Angsantikul, P.; Luk, B.; Zhang, Y.; Ying, M.; Jiang, Y.; Kroll, A.; Gao, W.; Zhang, L.* "Erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization", Advanced Materials 2017, 29, 1606209. [link] [journal cover]

Hu, J.; Bernatchez, C.; Zhang, L.; Xia X.; Kleinerman, E.; Hung, M-C.; Hwu, P.; Li, S. "Induction of NKG2D ligands on solid tumors requires tumor-specific CD8+ T cell and histone acetyltranserases", Cancer Immunology Research 2017, 5, 300-311. [link]

Fang, R.; Jiang, Y.; Fang, J.; Zhang, L.* "Cell membrane-derived nanomaterials for biomedical applications", Biomaterials 2017, 128, 69-83. [link]

Li, J.; Esteban-Fernandez de Avila, B.; Gao, W.; Zhang, L.*; Wang, J. "Micro/nanorobots for biomedicine: delivery, surgery, sensing and detoxification", Science Robotics 2017, 2, eaam6431. [link]

Li, J.; Angsantikul, P.; Liu, W.; Esteban-Fernandez de Avila, B.; Thamphiwatana, S.; Xu, M.; Sandraz, E.; Wang, X.; Delezuk, J.; Gao, W.; Zhang, L.*; Wang, J. "Micromotors spontaneously neutralize gastric acid for pH-responsive payload release", Angewandte Chemie International Edition 2017, 56, 2156-2161. [link]

Kroll, A.; Fang, R.; Zhang, L.* "Biointerfacing and applications of cell membrane-coated nanoparticles", Bioconjugate Chemistry 2017, 28, 23-32. [link]

Hopper, M.; Yun, J.; Zhou, B.; Le, C; Kehoe, K.; Le, R.; Hill, R.; Jongeward, G.; Debnath, A.; Zhang, L.; Miyamoto, Y.; Eckmann, L.; Lan, K.; Wrischnik, L. "Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo", International Journal of Antimicrobial Agents 2016, 48, 690-694. [link]

Wei, X.; Gao, J.; Fang, R.; Luk, B.; Kroll, A.; Dehaini, D.; Zhou, J.; Kim, H. W.; Gao, W.; Lu, W.; Zhang, L.* "Nanoparticles camouflaged in platelet membrane coating as an antibody decoy for the treatment of immune thrombocytopenia", Biomaterials 2016, 111, 116-123. [link]

Li, J.; Thamphiwatana, S.; Liu, W.; Esteban-Fernandez de Avila, B.; Angsantikul, P.; Sandraz, E.; Wang, J.; Xu, T.; Soto, F.; Ramez, V.; Wang, X.; Gao, W.; Zhang, L.*, Wang, J. "Enteric micromotor can selectively position and spontaneously propel in the gastrointestinal tract", ACS Nano 2016, 10, 9536-9542. [link]
Highlighted: Chemical & Engineering News October 18, 2016. [link]

Zhang, Q.; Li, J.; Gao, W.; Zhang, L.* "Nanoparticles for ocular drug delivery" in Ophthalmic Disease Mechanisms and Drug Discovery (Zhang, K., Ed), World Scientific Press, 2016, 197-225.

Dehaini, D.; Fang, R.; Luk, B.; Pang, Z.; Hu, C-M.; Kroll, A.; Yu, C. L.; Gao, W.; Zhang, L.* "Ultra-small lipid-polymer hybrid nanoparticles for tumor-penetrating drug delivery", Nanoscale 2016, 8, 14411-14419. [link]

Zhang, Y.; Zhang, J.; Chen, M.; Gong, H.; Thamphiwatana, S.; Eckmann, L.; Gao, W.; Zhang, L.* "A bioadhesive nanoparticle-hydrogel hybrid system for localized antimicrobial drug delivery", ACS Applied Materials & Interfaces 2016, 8, 18367-18374. [link]

Dehaini, D.; Fang, R.; Zhang, L.* "Biomimetic strategies for targeted nanoparticle delivery", Bioengineering & Translational Medicine 2016, 1, 30-46. [link]

Fang, R.; Zhang, L.* "Nanoparticle-based modulation of the immune system", Annual Review of Chemical and Biomolecular Engineering 2016, 7, 305-326. [link]

Gao, W.; Zhang, Y.; Zhang, Q.; Zhang, L.* "Nanoparticle-hydrogel: A hybrid biomaterial system for localized drug delivery", Annals of Biomedical Engineering 2016, 44, 2049-2061. [link]

Chen, W.; Zhang, Q.; Luk, B.; Fang, R.; Liu, Y.; Gao, W.; Zhang, L.* "Coating nanofiber scaffolds with beta cell membrane to promote cell proliferation and function", Nanoscale 2016, 8, 10364-10370. [link]

Luk, B.; Fang, R.; Hu, C-M.; Copp, J.; Thamphiwatana, S.; Dehaini, D.; Gao, W.; Zhang, K.; Li, S.; Zhang, L.* "Safe and immunocompatible nanocarriers cloaked in RBC membranes for drug delivery to treat solid tumors", Theranostics 2016, 6, 1004-1011. [link]

Lin, H.; Ouyang, H.; Zhu, J.; Huang, S.; Liu, Z.; Chen, S.; Cao, G.; Li, G.; Signer, R.; Xu, Y.; Chung, C.; Zhang, Y.; Lin, D.; Patel, S.; Wu, F.; Cai, H.; Hou, J.; Wen, C.; Jafari, M.; Liu, X.; Luo, L.; Zhu, J.; Qiu, A.; Hou, R.; Chen, B.; Chen, J.; Granet, D.; Heichel, C.; Shang, F.; Li, X.; Krawczyk, M.; Skowronska-Krawczyk, D.; Wang, Y.; Shi, W.; Chen, D.; Zhong, Z.; Zhong, S.; Zhang, L.; Chen, S.; Morrison, S.; Maas, R.; Zhang, K.; Liu. Y. "Lens regeneration using endogenous stem cells with gain of visual function", Nature 2016, 531, 323-328. [link]
Highlighted: Nature 2016, 531, 309-310 (News & Views). [link]

Wang, F.; Fang, R.; Luk, B.; Hu, C-M.; Thamphiwatana, S.; Dehaini, D.; Angsantikul, P.; Kroll, A.; Pang, Z.; Gao, W.; Lu, W.; Zhang, L.* "Nanoparticle-based anti-virulence vaccine for the management of methicillin-resistant Staphylococcus aureus skin infection", Advanced Functional Materials 2016, 26, 1628-1635. [link]

Angell, C.; Xie, S.; Zhang, L.; Chen, Y. "DNA nanotechnology for precise control over drug delivery and gene therapy", Small 2016, 12, 1117-1132. [link]

Luk, B.; Zhang, L.* "Cell membrane-camouflaged nanoparticles for drug delivery", Journal of Controlled Release 2015, 220, 600-607. [link]

Wu, Z.; Li, J.; Esteban-Fernandez de Avila, B.; Li, T.; Gao, W.; He, Q.; Zhang, L.*; Wang, J. "Water-powered cell-mimicking Janus micromotor", Advanced Functional Materials 2015, 25, 7497-7501. [link]

Fang, R.; Kroll, A.; Zhang, L.* "Nanoparticle-based manipulation of antigen presenting cells for cancer immunotherapy", Small 2015, 11, 5483-5496. [link] [journal cover]

Gao, W.; Zhang, L.* "Coating nanoparticles with cell membranes for targeted drug delivery", Journal of Drug Targeting 2015, 23, 619-626. (Special Issue Honoring Dr. Robert Langer) [link]

Angsantikul, P.; Thamphiwatana, S.; Gao, W.; Zhang, L.* "Cell membrane-coated nanoparticles as an emerging antibacterial vaccine platform", Vaccines 2015, 3, 814-828. [link]

Hu, C-M.; Fang, R.; Wang, K-C.; Luk, B.; Thamphiwatana, S.; Dehaini, D.; Nguyen, P.; Angsantikul, P.; Wen, C.; Kroll, A.; Carpenter, C.; Ramesh, M.; Qu, V.; Patel, S.; Zhu, J.; Shi, W.; Hofman, F.; Chen, T.; Gao, W; Zhang, K.; Chien, S.; Zhang, L.* "Nanoparticle biointerfacing by platelet membrane cloaking", Nature 2015, 526, 118-121. [link]
Highlighted: Nature 2015, 526, 47-48 (News & Views). [link]
                    Nature News September 16, 2015. [link]
                    Nature Podcast September 16, 2015. [link]
                    Science Translational Medicine 2015, 7 (307), 307ec169. [link]

Zhang, J., Gao, W.; Fang, R.; Dong, A.; Zhang, L.* "Synthesis of nanogels via cell membrane-templated polymerization", Small 2015, 11, 4309-4313. [link]

Skowronska-Krawczyk, D.; Zhao, L.; Zhu, J.; Weinreb, R.N.; Cao, G.; Luo, J.; Flagg, K.; Patel, S.; Wen C.; Krupa, M.; Luo, H.; Ouyang, H.; Lin, D.; Wang, W.; Li, G.; Xu, Y.; Li, O.; Chung, C.; Yeh, E.; Jafari, M.; Ai, M.; Zhong, Z.; Shi, W.; Zheng, L.; Krawczyk, M.; Chen, D.; Shi, C.; Zin, C.; Zhu, J.; Mellon, P.L.; Gao, W.; Abagyan, R.; Zhang, L.; Sun, X.; Zhong, S.; Zhuo, Y,; Rosenfeld, M.G.; Liu, Y.; Zhang, K. "P16INK4a upregulation mediated by SIX6 defines retinal ganglion cell pathogenesis in glaucoma", Molecular Cell 2015, 59, 931-940. [link]

Wu, Z.; Esteban-Fernandez de Avila, B.; Martin, A.; Christianson, C.; Gao, W.; Thamphiwatana, S.; Escarpa, A.; He, Q.; Zhang, L.*; Wang, J. "RBC micromotors carrying multiple cargos towards potential theranostic applications", Nanoscale 2015, 7, 13680-13686. [link]

Fang, R.; Luk, B.; Hu, C-M.; Zhang, L.* "Engineered nanoparticles mimicking cell membranes for toxin neutralization", Advanced Drug Delivery Reviews 2015, 90, 69-80. [link] [journal cover]

Zhang, L.*; Leroux, J-C. "Current and forthcoming approaches for systemic detoxification", Advanced Drug Delivery Reviews 2015, 90, 1-2. (Editorial) [link]

Zhao, L.; Chen, X.; Zhu, J.; Xi, Y.; Yang, X.; Hu, L.; Patel, S.; Jin, X.; Lin, D.; Wu, F.; Flagg, K.; Cai, H.; Li, G.; Cao, G.; Ouyang, H.; Chen, D.; Wen, C.; Qiu, A.; Yeh, E.; Wang, W.; Hu, X.; Grob, S.; Abagyan, R.; Lin, Y.; Su, Z.; Tjondro, H.; Zhao, X.; Luo, H.; Hou, R.; Chung, C.; Perry, J.; Gao, W.; Kozak, I.; Granet, D.; Li, Y.; Sun, X.; Wang, J.; Zhang, L.*; Liu, Y.; Yan, Y.; Zhang, K. "Lanosterol reverses protein aggregation in cataract", Nature 2015, 523, 607-611. [link]
Highlighted: Nature 2015, 523, 540-541 (News & Views). [link]
                    Science July 22, 2015. [link]

Esteban-Fernandez de Avila, B.; Martin, A.; Soto, F.; Ramirez, M.; Campuzano, S.; Vasquez-Machado, G. M.; Gao, W.; Zhang, L.*; Wang, J. "Single cell real time miRNA sensing based on nanomotors", ACS Nano 2015, 9, 6756-6764. [link]

Pang, Z.; Hu, C-M. J.; Fang, R. H.; Luk, B. T.; Gao, W.; Wang, F.; Chuluun, E.; Angsantikul, P.; Thamphiwatana, S.; Lu, W.; Jiang, X.; Zhang, L.* "Detoxification of organophosphate poisoning using nanoparticle bioscavengers", ACS Nano 2015, 9, 6450-6458. [link]

Wu, Z.; Li, T.; Gao, W.; Xu, T.; Jurado-Sanchez, B.; Li, J.; Gao, W.; He, Q.; Zhang, L.*; Wang, J. "Cell membrane-coated synthetic nanomotors for effective biodetoxification", Advanced Functional Materials 2015, 25, 3881-3887. [link]

Wang, F.; Gao, W.; Thamphiwatana, S.; Luk, B.; Angsantikul, P.; Zhang, Q.; Hu, C-M.; Fang, R.; Copp, J.; Pornpattananangkul, D.; Lu, W.; Zhang, L.* "Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection", Advanced Materials 2015, 27, 3437-3443. [link] [journal cover]

Krishnamurthy, S.; Vaiyapuri, R.; Zhang, L.; Chan, J. "Lipid-coated polymeric nanoparticles for cancer drug delivery", Biomaterials Science, 2015, 3, 923-936. [link]

Futalan, D.; Saenz, R.; Bharati, I.; Seible, D.; Zhang, L.; Esener, S.; Messmer, B.; Larsson, M.; Messmer, D. "Enhanced anti-tumor immune response and delay of tumor development in HER2 mice immunized with immunostimulatory peptides in PLGA nanoparticles", Breast Cancer Research 2015, 17, 48. [link]

Jung, S. W.; Thamphiwatana, S.; Zhang, L.*; Obonyo, M. "Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori", PLOS ONE 2015, 10(3), e0116519. [link]

Sanchez-Gaytan, B. L.; Fay, F.; Lobatto, M. E.; Tang, J.; Ouimet, M.; Kim, Y. T.; van der Staay, S.; van Rijs, S.; Priem, Z.; Zhang, L.; Fisher, E. A.; Moore, K.; Langer, R.; Fayad, Z. A.; Mulder, W. J. "HDL-mimetic PLGA nanoparticle for the targeting of atherosclerosis plaque macrophages", Bioconjugate Chemistry, 2015, 26, 443-451. [link]

Gao, W.; Zhang, L.* "Engineering red blood cell membrane-coated nanoparticles for broad biomedical applications", AIChE Journal 2015, 61, 738-746. (Perspective: 2014 AIChE Allan P. Colburn Award) [link] [journal cover]
Highlighted: CEP Magazine March, 2015. [link]

Gao, W.; Fang, R.; Thamphiwatana, S.; Luk, B.; Li, J.; Angsantikul, P.; Zhang, Q.; Hu, C-M.; Zhang, L.* "Modulating antibacterial immunity via bacterial membrane-coated nanoparticles", Nano Letters 2015, 15, 1403-1409. [link]

Gao, W.; Dong, D.; Thamphiwatana, S.; Li, J.; Gao, W.; Zhang, L.*; Wang, J. "Artificial micromotors in the mouse's stomach: A step towards in vivo use of synthetic motors", ACS Nano 2015, 9, 117-123. [link]
Highlighted: Chemical & Engineering News January 21, 2015. [link]

Wu, Z.; Li, T.; Li, J.; Gao, W.; Xu, T.; Christianson, C.; Gao, W.; Galarnyk, M.; He, Q.; Zhang, L.*; Wang, J. "Turning erythrocytes to functional micromotors", ACS Nano 2014, 8, 12041-12048. [link]

Luk, B.; Zhang, L.* "Current advances in polymer-based nanotheranostics for cancer treatment and diagnosis", ACS Applied Materials & Interfaces 2014, 6, 21859-21873. [link]

Thamphiwatana, S.; Gao, W.; Obonyo, M.; Zhang, L.* "In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation", Proceedings of the National Academy of Sciences 2014, 111, 17600-17605. [link]
Highlighted: Nature Reviews Gastroenterology & Hepatology 2015, 12, 5. [link]

Thamphiwatana, S.; Gao, W.; Pornpattananangkul, D.; Zhang, Q.; Fu, V.; Li, J.; Li, J.; Obonyo, M.; Zhang, L.* "Phospholipase A2-responsive antibiotic delivery via nanoparticle-stabilized liposomes for the treatment of bacterial infection", Journal of Materials Chemistry B 2014, 2, 8201-8207. [link]

Gao, W.; Thamphiwatana, S.; Angsantikul, P.; Zhang, L.* "Nanoparticle approaches against bacterial infections", WIREs Nanomedicine & Nanobiotechnology 2014, 6, 532-547. [link]

Copp, J.; Fang, R. Luk, B.; Hu, C-M.; Gao, W.; Zhang, K.; Zhang, L.* "Clearance of pathological antibodies using biomimetic nanoparticles", Proceedings of the National Academy of Sciences 2014, 111, 13481-13486. [link]
Highlighted: Proceedings of the National Academy of Sciences 2014, 111, 13243-13244. [link]

Hu, C-M.; Zhang, L.* "Nanotoxoid vaccines", Nano Today 2014, 9, 401-404. [link]

Sattayasamitsathit, S.; Kou, H.; Gao, W.; Thavarajah, W.; Kaufmann, K.; Zhang, L.*; Wang, J. "Fully-loaded micromotors for combinatorial delivery and autonomous release of cargoes", Small 2014, 10, 2830-2833. [link]

Ouyang, H.; Xue, Y.; Lin, Y.; Zhang, X.; Xi, L.; Patel, S.; Cai, H.; Luo, J.; Zhang, M.; Zhang, M.; Yang, Y.; Li, G.; Li, H.; Jiang, W.; Yeh, E.; Lin, J.; Pei, M.; Zhu, J.; Cao, G.; Zhang, L.; Yu, B.; Chen, S.; Fu, X-D.; Liu, Y.; Zhang, K. "WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis", Nature 2014, 511, 358-361. [link]

Yu, F-X.; Luo, J.; Mo, J-S.; Liu, G.; Kim, Y. C. ; Meng, Z.; Zhao, L.; Peyman, G.; Ouyang, H.; Jiang, W.; Chen, X.; Zhang, L.; Wang, C-Y.; Bastian, B. C.; Zhang, K.; Guan, K-L. "Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP", Cancer Cell 2014, 25, 822-830. [link]

Fang, R.; Zhang, L.* "Combinatorial nanotherapeutics: Rewiring, then killing, cancer cells", Science Signaling 2014, 7, pe13. [link]

Fang, R.; Hu, C-M.; Luk, B.; Gao, W.; Copp, J.; Tai, Y.; O'Connor, D.; Zhang, L.* "Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery", Nano Letters 2014, 14, 2181-2188. [link]

Gao, W.; Vecchio, D.; Li, J.; Zhu, J.; Zhang, Q.; Fu, V.; Li, J.; Thamphiwatana, S.; Lu, D.; Zhang, L.* "Hydrogel containing nanoparticle-stabilized liposomes for topical antimicrobial delivery", ACS Nano 2014, 8, 2900-2907. [link]
Highlighted: Nature Nanotechnology 2014, 9, 161. [link]

Luk, B.; Hu, C-M.; Fang, R.; Dehaini, D.; Carpenter, C.; Gao, W.; Zhang, L.* "Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles", Nanoscale 2014, 6, 2730-2737. [link]

Hu, J.; Zhu, S.; Xia, X.; Zhang, L.; Kleinerman, E. S.; Li, S. "CD8+T cell-specific induction of NKG2D receptor by doxorubicin plus interleukin-12 and its contribution on CD8+T cell accumulation in tumors", Molecular Cancer 2014, 13, 34. [link]

Sukumar, R.; Sethi, M.; Karve, S.; Werner, M.; Moore, D.; Zhang, L.; Wang, A. Z. "Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicity", Nanoscale 2014, 6, 2321-2327. [link]

Hu, C-M.; Fang, R.; Luk, B.; Zhang, L.* "Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies", Nanoscale 2014, 6, 65-75. [link]

Hu, C-M.; Fang, R.; Luk, B.; Zhang, L.* "Nanoparticle-detained toxins for safe and effective vaccination",       Nature Nanotechnology 2013, 8, 933-938. [link]
Highlighted: Science 2013, 342, 1418. [link]
                    NIH Director's Blog, December 12, 2013. [link]
                    MIT Technology Review, January 3, 2014. [link]

Gao, W.; Hu, C-M.; Fang, R.; Zhang, L.* "Liposome-like nanostructures for drug delivery", Journal of Materials Chemistry B, 2013, 1, 6569-6585. [link]

Fang, R.; Hu, C-M.; Chen, K.; Luk, B.; Carpenter, C.; Gao, W.; Li, S.; Zhang, D-E.; Lu, W.; Zhang, L.* "Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles", Nanoscale 2013, 5, 8884-8888. [link]

Pornpattananangkul, D.; Fu, V.; Thamphiwatana, S.; Zhang, L.; Chen, M.; Vecchio, J.; Gao, W.; Huang, C-M.; Zhang, L.* "In vivo treatment of Propionibacterium acnes infection with liposomal lauric acids", Advanced Healthcare Materials 2013, 2, 1322-1328. [link]

Thamphiwatana, S.; Fu, V.; Zhu, J.; Lu, D.; Gao, W.; Zhang, L.* "Nanoparticle-stabilized liposomes for pH-responsive gastric drug delivery", Langmuir 2013, 29, 12228-12233. [link]

Aryal, S.; Hu, C-M.; Fang, R.; Dehaini, D.; Carpenter, C.; Zhang, D-E.; Zhang, L.* "Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release", Nanomedicine 2013, 8, 1271-1280. [link]

Gao, W.; Hu, C-M.; Fang, R.; Luk, B.; Su, J.; Zhang, L.* "Surface functionalization of gold nanoparticles with red blood cell membranes", Advanced Materials 2013, 25, 3549-3553. [link] [journal cover]

Hu, C-M.; Fang, R.; Copp, J.; Luk, B.; Zhang, L.* "A biomimetic nanosponge that absorbs pore-forming toxins", Nature Nanotechnology 2013, 8, 336-340. [link] [animation]
Highlighted: Science Translational Medicine 2013, 5 (184), 184ec78. [link]
                    Nano Today, 2013, 8, 217-218. (News and Opinions) [link]
                    MIT Technology Review, April 14, 2013. [link]

Hu, C-M.; Fang, R.; Luk, B.; Chen, K.; Carpenter, C.; Gao, W.; Zhang, K.; Zhang, L.* "'Marker-of-self' functionalizaton of nanoscale particles through a top-down cellular membrane coating approach", Nanoscale 2013, 5, 2664-2668. [link]

Kong, S.; Sartor, M.; Hu, C-M.; Zhang, W.; Zhang, L.*; Jin, S. "Magnetic field activated lipid-polymer hybrid nanoparticles for stimuli-responsive drug release", Acta Biomaterialia 2013, 9, 5447-5452. [link]

Zhao, J.; Sun, W.; Cho, H. M.; Ouyang, H.; Li, W.; Lin, Y.; Do, J.; Zhang, L.; Ding, S.; Liu, Y.; Lu, P.; Zhang, K. "Integration and long distance axonal regeneration in the central nervous system from transplanted primitive neural stem cells", Journal of Biological Chemistry 2013, 288, 164-168. [link]

Gao, W.; Zhang, L.* "Unleash the forces within", Nature Chemistry 2012, 4, 971-972. [link]

Luk, B. T.; Fang, R. H.; Zhang, L.* "Lipid- and polymer-based nanostructures for cancer theranostics", Theranostics 2012, 2, 1117-1126. [link]

Fang, R.; Chen, K.; Aryal, S.; Hu, C-M.; Zhang, K.; Zhang, L.* "Large-scale synthesis of lipid-polymer hybrid nanoparticles using a multi-inlet vortex reactor", Langmuir 2012, 28, 13824-13829. [link]

Hu, C-M.; Fang, R. H.; Zhang, L.* "Erythrocyte-inspired delivery systems", Advanced Healthcare Materials      2012, 1, 537-547. [link]

Obonyo, M.; Zhang, L.; Thamphiwatana, S.; Pornpattananangkul, D.; Fu, V.; Zhang, L.* "Antibacterial activities of liposomal linolenic acids against antibiotic-resistant Helicobacter pylori", Molecular Pharmaceutics 2012, 9, 2677-2685. [link]

Shaw, P. X.; Zhang, L.; Zhang, M.; Du, H.; Zhao, L.; Lee, C.; Crob, S.; Lim, S. L.; Hughes, G.; Lee, J.; Bedell, M.; Nelson, M. H.; Lu, F.; Luo, J.; Ouyang, H.; Tu, Z.; Su, Z.; Zhu, J.; Wei, X.; Feng, Z.; Duan, Y.; Yang, Z.; Ferreyra, F.; Bartsch, D-U.; Kozak, I.; Zhang, L.; Lin, F.; Sun, H.; Feng, H.; Zhang, K. "Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids", Proceedings of the National Academy of Sciences 2012, 109, 13757-13762. [link]

Zhang, K.; Zhang, L.; Weinreb, R. N. "Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma", Nature Reviews Drug Discovery 2012, 11, 541-559. [link]

Fang, R. H.; Hu, C-M.; Zhang, L.* "Nanoparticles disguised as red blood cells to evade the immune system", Expert Opinion on Biological Therapy 2012, 12, 385-389. [link]

Aryal, S.; Hu, C-M.; Zhang, L.* "Synthesis of Ptsome: A platinum-based liposome-like nanostructure", Chemical Communications 2012, 48, 2630-2632. [link]

Hu, C-M.; Zhang, L.* "Nanoparticle-based combination therapy toward overcoming drug resistance in cancer", Biochemical Pharmacology 2012, 83, 1104-1111. [link]

Gao, W.; Kagan, D.; Pak, O. ; Clawson, C.; Campuzano, S.; Erdene, E. C.; Fullerton, E.; Zhang, L.*; Lauga, E.; Wang, J. "Cargo-towing fuel-free magnetic nanomotors for targeted drug delivery", Small 2012, 8, 460-467. [link]

Aryal, S.; Hu, C-M.; Fu, V.; Zhang, L.* "Nanoparticle drug delivery enhances the cytotoxicity of hydrophobic- hydrophilic drug conjugates", Journal of Materials Chemistry 2012, 22, 994-999. [link]

Clawson, C.; Ton, L.; Aryal, S.; Fu, V.; Esener, S.; Zhang, L.* "Synthesis and characterization of lipid-polymer hybrid nanoparticles with pH-triggered PEG shedding", Langmuir 2011, 27, 10556-10561. [link]

Fang, R. H.; Zhang, L.* "Dispersion-based methods for the engineering and manufacture of polymeric nanoparticles for drug delivery applications", Journal of Nanoengineering and Nanomanufacturing 2011, 1, 106-112. [link]

Aryal, S.; Hu, C-M.; Zhang, L.* "Polymeric nanoparticles with precise ratiometric control over drug loading for combination therapy", Molecular Pharmaceutics 2011, 8, 1401-1407. [link]

Hu, C-M.; Zhang, L.; Aryal, S.; Cheung, C.; Fang, R. H.; Zhang, L.* "Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform", Proceedings of the National Academy of Sciences 2011, 108, 10980-10985. [link]
Highlighted: Nano Today 2011, 6, 327. (News and Opinions) [link]
                    National Academy of Engineering, "Engineering Innovation" Radio News [link]

Balasubramanian, S.; Kagan, D.; Hu, C-M.; Campuzano, S.; Lobo-Castañon, M. J.; Lim, N.; Kang, D.; Zhang, L.*; Wang, J. "Nanomachine enabled selection and isolation of cancer cells in complex media", Angewandte Chemie International Edition 2011, 50, 4161-4164. [link] [journal cover]
Highlighted: Angewandte Chemie International Edition 2011, 50, 7220-7221. [link]
                    Chemical & Engineering News 2011, 89 (18), 6. [link]

Chen, C-H.; Wang, Y.; Liu, Y-T.; Zouboulis, C.; Gallo, R. L.; Zhang, L.*; Hsieh, M-F.; Huang, C-M. "An innate bactericidal oleic acid effective against skin infection of methicillin-resistant Staphylococcus aureus: a therapy concordant with evolutionary medicine", Journal of Microbiology and Biotechnology 2011, 21, 391-399. [link]

Nakatsuji, T.; Tang, D-C.; Zhang, L.; Gallo, R. L.; Huang, C-M. "Propionibacterium acnes CAMP factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment",
PLOS ONE 2011, 6(4), e14797. [link]

Pornpattananangkul, D.; Zhang, L.; Olson, S.; Aryal, S.; Obonyo, M.; Vecchio, K.; Huang, C-M.; Zhang, L.* "Bacterial toxin-triggered drug release from gold nanoparticle-stabilized liposomes for the treatment of bacterial infection", Journal of the American Chemical Society 2011, 133, 4132-4139. [link]
Highlighted: Chemical & Engineering News 2011, 89 (10), 42. [link]

Clawson, C.; Esener, S.; Zhang, L.* "Lipid-Polymer Nanomaterials" in Polymeric Nanomaterials (Kumar, C., Ed), Wiley-VCH Press, 2011, 259-284.

Huang, C-M.; Chen, C-H.; Pornpattananangkul, D.; Zhang, L.; Chan, M.; Hsieh, M-F.; Zhang, L.* "Eradication of drug resistant Staphylococcus aureus by liposomal oleic acids", Biomaterials 2011, 32, 214-221. [link]

Kagan, D.; Laocharoensuk, R.; Zimmerman, M.; Clawson, C.; Balasubramanian, S.; Kang, D.; Bishop, D.; Sattayasamitsathit, S.; Zhang, L.*; Wang, J. "Rapid delivery of drug carriers propelled and navigated by catalytic nanoshuttles", Small 2010, 6, 2741-2747. [link]
Highlighted: Nature Materials 2010, 9, 958. [link]

Fang, R. H.; Aryal, S.; Hu, C-M.; Zhang, L.* "Quick synthesis of lipid-polymer hybrid nanoparticles with low polydispersity using a single-step sonication method", Langmuir 2010, 26, 16958-16962. [link]

Zhang, L.; Zhang, L*"Lipid-polymer hybrid nanoparticles: synthesis, characterization and applications",
Nano LIFE 2010, 1, 163-173. [link]

Hu, C-M.; Aryal, S.; Zhang, L.* "Nanoparticles assisted combination therapies for effective cancer treatment", Therapeutic Delivery 2010, 1, 323-334. [link]

Aryal, S.; Hu, C-M.; Zhang, L.* "Combinatorial drug conjugation enabled nanoparticle dual drug delivery",
Small 2010, 6, 1442-1448. [link]

Chumbimuni-Torres, K. Y.; Wu, J.; Clawson, C.; Galik, M.; Walter, A.; Flechsig, G-U.; Bakker, E.; Zhang, L.*; Wang, J. "Amplified potentiometric transduction of DNA hybridization using ion-loaded liposomes", Analyst 2010, 135, 1618-1623. [link]

Hu, C-M,; Kaushal, S.; Tran Cao, H. S.; Aryal, S.; Sartor, M.; Esener, S.; Bouvet, M.; Zhang, L.* "Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cells", Molecular Pharmaceutics 2010, 7, 914-920. [link]

Pornpattananangkul, D.; Olson, S.; Aryal, S.; Sartor, M.; Huang, C-M.; Vecchio, K. S.; Zhang, L.* "Stimuli-responsive liposome fusion mediated by gold nanoparticles", ACS Nano 2010, 4, 1935-1942. [link]
Highlighted: Nanomedicine 2010, 5, 530. [link]

Wang, A.; Yuet, K.; Zhang, L.; Gu, F.; Huynh-Le, M.; Radovic-Moreno, A.; Langer, R.; Farokhzad, O. C. "ChemoRad nanoparticles: A novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation", Nanomedicine 2010, 5, 361-368. [link]

Valencia, P.; Basto, P., Zhang, L.; Rhee, M.; Langer, R.; Farokhzad, O. C.; Karnik, R. "Single-step assembly of homogeneous lipid-polymeric and lipid-quantum dots nanoparticles enabled by microfluidic rapid mixing",
ACS Nano 2010, 4, 1671-1679. [link]

Nakatsuji, T.; Kao, M. C.; Zhang, L.; Zouboulis, C. C.; Gallo, R. L.; Huang, C-M. "Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating ß-defensin-2 expression", Journal of Investigative Dermatology 2010, 130, 985-994. [link]

Chan, J.; Zhang, L.; Tong, R.; Ghosh, D.; Gao, W.; Liao, G.; Yuet, K.; Gray, D.; Rhee, J-W.; Cheng, J.; Golomb, G.; Libby, P.; Langer, R.; Farokhzad, O. C. "Spatiotemporal controlled delivery of nanoparticles to injured vasculature", Proceedings of the National Academy of Sciences 2010, 107, 2213-2218. [link]

Chan, J.; Valencia, M. P.; Zhang, L.; Langer, R.; Farokhzad, O. C. "Polymer nanoparticles for drug delivery" in Cancer Nanotechnology: Methods and Protocols (Grobmyer, S. and Moudgil, B., Eds.), Springer Press, USA, 2010, 163-175. [link]

Aryal, S.; Hu, C-M.; Zhang, L.* "Polymer-cisplatin conjugate nanoparticles for acid-responsive drug delivery",
ACS Nano 2010, 4, 251-258. [link]

Zhang, L.*; Pornpattananangkul, D.; Hu, C-M.; Huang, C-M. "Development of nanoparticles for antimicrobial drug delivery", Current Medicinal Chemistry 2010, 17, 585-594. [link]

Hu, C-M.; Zhang, L.* "Therapeutic nanoparticles to combat cancer drug resistance", Current Drug Metabolism 2009, 10, 836-841. [link]

Mora, L.; Chumbimuni-Torres, K. Y.; Clawson, C.; Hernandez, L.; Zhang, L.*; Wang, J. "Real-time electrochemical monitoring of drug release from therapeutic nanoparticles", Journal of Controlled Release 2009, 140, 69-73. [link]

Yang, D.; Pornpattananangkul, D.; Nakatsuji, T.; Chan, M.; Carson, D.; Huang, C-M.; Zhang, L.* "The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes", Biomaterials 2009, 30, 6035-6040. [link]

Nakatsuji, T.; Kao, M. C.; Fang, J-Y.; Zouboulis, C. C.; Zhang, L.; Gallo, R. L.; Huang, C-M. "Antimicrobial property of lauric acid against propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris",
Journal of Investigative Dermatology 2009, 129, 2480-2488. [link]

Salvador-Morales, C.; Zhang, L.; Langer, R.; Farokhzad, O. C. "Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups", Biomaterials 2009, 30, 2231-2240. [link]

Chan, J.; Zhang, L.; Yuet, K.; Liao, G.; Rhee, J-W.; Langer, R.; Farokhzad, O. C. "PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery", Biomaterials 2009, 30, 1627-1634. [link]

Alexis, F.; Basto, P.; Levy-Nissenbaum, E.; Radovic-Moreno, A.; Zhang, L.; Pridgen, E.; Wang, A.; Molnar, S.; Westerhof K.; Farokhzad, O. C. "HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy", ChemMedChem 2008, 3, 1839-1843. [link]

Wang, B.; Zhang, L.; Bae, S. C.; Granick, S. "Nanoparticle-induced surface reconstruction of phospholipid membranes", Proceedings of the National Academy of Sciences 2008, 105, 18171-18175. [link]
Highlighted: Nature Nanotechnology 2008, doi:10.1038/nnano.2008.371. [link]

Wang, A.; Bagalkot, V.; Vasilliou, C.; Gu. F.; Alexis, F.; Zhang, L.; Shaikh, M. R.; Yuet, K.; Cima, M.; Langer, R.; Kantoff, P. W.; Bander, N. H.; Jon, S.; Farokhzad, O. C. "Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy", ChemMedChem 2008, 3, 1311-1315. [link]

Zhang, L. ; Chan, J.; Gu, F.; Rhee, J-W.; Wang, A.; Radovic-Moreno, A.; Alexis, F.; Langer, R.; Farokhzad, O. C. "Self-assembled lipid-polymer hybrid nanoparticles: A robust drug delivery platform", ACS Nano 2008, 2, 1696-1702. [link]

Wang, A.; Gu, F.; Zhang, L.; Chan, J.; Radovic-Modovic, A.; Shaikh, M. R.; Farokhzad, O. C. "Biofunctionalized targeted nanoparticles for therapeutic applications", Expert Opinion on Biological Therapy 2008, 8, 1063-1070. [link]

Zhang, L.; Gu, F.; Chan, J.; Wang, A.; Langer, R.; Farokhzad, O. C. "Nanoparticles in medicine: Therapeutic applications and developments", Clinical Pharmacology & Therapeutics 2008, 83, 761-769. [link]

Gu, F.; Zhang, L.; Teply, B.; Mann, N.; Wang, A.; Radovic-Moreno, A.; Langer, R.; Farokhzad, O. C. "Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers",
Proceedings of the National Academy of Sciences 2008, 105, 2586-2591. [link]

Bagalkot, V.; Zhang, L.; Levy-Nissenbaum, E.; Jon, S.; Kantoff, P. W.; Langer, R.; Farokhzad, O. C. "Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy and sensing of drug delivery based on bi-fluorescence resonance energy transfer", Nano Letters 2007, 7, 3065-3070. [link]

Zhang, L.; Radovic-Moreno, A.; Alexis, F.; Gu, F.; Basto, P. A.; Bagalkot, V.; Jon, S.; Langer, R.; Farokhzad, O. C. "Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates", ChemMedChem 2007, 2, 1268-1271. [link]

Yu, Y.; Anthony, S.; Zhang, L.; Bae, S. C.; Granick, S. "Cationic nanoparticles stabilize zwitterionic liposomes better than anionic ones", Journal of Physical Chemistry C 2007, 111, 8233-8236. [link]

Zhang, L.; Dammann, K.; Bae, S. C. Granick, S. "Ligand-receptor binding on nanoparticle-stabilized liposome surfaces", Soft Matter 2007, 3, 551-553. [link]

Zhang, L.; Granick, S. "Inter-leaflet diffusion coupling when polymer adsorbs onto one sole leaflet of a supported phospholipid bilayer", Macromolecules 2007, 40, 1366-1368. [link]

Zhang, L.; Hong, L.; Yu, Y.; Bae, S. C.; Granick, S. "Nanoparticle-assisted surface immobilization of phospholipid liposomes", Journal of the American Chemical Society 2006, 128, 9026-9027. [link]

Zhang, L.; Granick, S. "Dynamical heterogeneity in supported lipid bilayers", MRS Bulletin 2006, 31, 527-531. [link]

Anthony, S.; Zhang, L.; Granick, S. "Methods to track single-molecule trajectories", Langmuir 2006, 22, 5266-5272. [link]

Zhang, L.; Granick, S. "How to stabilize phospholipid liposomes (using nanoparticles)", Nano Letters 2006, 6, 694-698. [link]
Highlighted: Science 2006, 311, 1347. [link]; Nature Materials 2006, 5, 249. [link]

Zhang, L.; Spurlin, T. A.; Gewirth, A. A.; Granick, S. "Electrostatic stitching in gel-phase supported phospholipid bilayers", Journal of Physical Chemistry B 2006, 110, 33-35. [link]
Highlighted: Science 2005, 310, 1871. [link]

Zhang, L.; Granick, S. "Lipid diffusion compared in outer and inner leaflets of planar supported bilayers",
Journal of Chemical Physics 2005, 123, 211104/1-4. [link]

Zhang, L.; Granick, S. "Slaved diffusion in phospholipid bilayers", Proceedings of the National Academy of Sciences 2005, 102, 9118-9121. [link]