University of California
San Diego

Departments of Nanoengineering
and Bioengineering

Jennifer Marciniak, Ph.D

 

Current Research

DEP applications
One way to detect the presence of cancer is to find rare cells or other particulates in the blood. One challenge facing many techniques is the amount of preparation that must be done to ready the sample for testing. The more the sample has to be handled before testing is begun, the more there is a chance of losing the cell or enzyme that we are looking for. Also, it is not beneficial to take a large amount of blood from a sick patient. We are working on a way to use dielectrophoresis in order to minimize the amount of sample preparation that is needed to detect biomarkers of interest directly in the blood.

 

Publications

J.Y. Marciniak, A.C. Kummel, S.C. Esener, M.J. Heller, B.T. Messmer, Coupled rolling circle amplification – loop mediated amplification (RCA-LAMP) for rapid detection of short DNA sequences. BioTechniques, 2008. 45(3): p. 275-280

D. Volfson*, J. Marciniak*, W.J. Blake, N. Ostroff, L.S. Tsimring, and J. Hasty, Origins of extrinsic variability in eukaryotic gene expression. Nature, 2006. 439: p. 861-864
*co-first authors

S.S. Fong, J.Y. Marciniak, and B.O. Palsson, Description and interpretation of adaptive evolution of Escherichia coli K-12 MG1655 by using a genome-scale in silico metabolic model. J Bacteriol, 2003. 185(21): p. 6400-8.